Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 7/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.35 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.34 |
| ▸ | MET | P08581 | 2/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | CCNK | O75909 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CCNH | P51946 | 1/20 | 0.34 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6030341 | 0.88 | CHEK1 (0.36) | CHEK1PRKCZPRKD2JAK1JAK3 | |
| SCHEMBL6028349 | 0.87 | LMNA (0.41) | CHEK1PDPK1 | |
| SCHEMBL6030280 | 0.87 | NTRK1 (0.39) | CHEK1JAK1JAK3KCNH2F10 | |
| SCHEMBL6028983 | 0.87 | CDK2 (0.38) | CHEK1JAK1JAK3KCNH2F10 | |
| SCHEMBL6029129 | 0.86 | CHEK1 (0.35) | CHEK1PRKCZPRKD2JAK1JAK3 | |
| SCHEMBL6028919 | 0.85 | CHEK1 (0.39) | CHEK1JAK1JAK3KCNH2 | |
| SCHEMBL6029102 | 0.85 | CHEK1 (0.39) | CHEK1 | |
| SCHEMBL6028900 | 0.83 | CDK8 (0.36) | CHEK1JAK1JAK3CCNKCDK7 | |
| SCHEMBL6028834 | 0.80 | LMNA (0.42) | CHEK1MAPKAPK2 | |
| SCHEMBL6029595 | 0.79 | NPC1 (0.37) | CHEK1JAK1JAK3KCNH2CCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984643-B2 | 2,5-substituted pyrimidine derivatives-CCR-3 receptor antagonists | ROCHE PALO ALTO LLC (US) | 2006-01-10 | — | — | US | disclosed |