Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 3/20 | 0.34 |
| ▸ | CCNK | O75909 | 3/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CDK7 | P50613 | 2/20 | 0.34 |
| ▸ | CCNH | P51946 | 2/20 | 0.34 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.34 |
| ▸ | MC4R | P32245 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6028983 | 0.91 | CDK2 (0.38) | GAAMAPK1KMT2ALMNACDK2 | |
| SCHEMBL6029187 | 0.91 | MAPT (0.38) | MAPTKMT2ALMNACHEK1 | |
| SCHEMBL6028919 | 0.90 | CHEK1 (0.39) | CDK9CCNT1MC4RNTRK1CHEK1 | |
| SCHEMBL6029102 | 0.89 | CHEK1 (0.39) | GAAMAPK1KMT2ALMNACCNT1 | |
| SCHEMBL6028843 | 0.88 | LMNA (0.38) | MAPTMAPK1LMNA | |
| SCHEMBL6030280 | 0.86 | NTRK1 (0.39) | MAPTKMT2ACDK9CCNT1MC4R | |
| SCHEMBL6030341 | 0.85 | CHEK1 (0.36) | GAAMC4RCHEK1JAK1JAK3 | |
| SCHEMBL6029129 | 0.84 | CHEK1 (0.35) | GAAMAPTLMNAMC4RCHEK1 | |
| SCHEMBL6028338 | 0.83 | CHEK1 (0.40) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL6029595 | 0.81 | NPC1 (0.37) | GAAMAPTMAPK1SMN1; SMN2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984643-B2 | 2,5-substituted pyrimidine derivatives-CCR-3 receptor antagonists | ROCHE PALO ALTO LLC (US) | 2006-01-10 | — | — | US | disclosed |