Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 5/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9358413 | 0.98 | PGR (0.42) | PGRIDO1CYP46A1ALDH1A1CYP1A2 | |
| SCHEMBL24725924 | 0.76 | MRGPRX2 (0.40) | AR | |
| SCHEMBL6539867 | 0.76 | AR (0.38) | PGRARMEN1KMT2AHTR2A | |
| SCHEMBL5460910 | 0.76 | AR (0.47) | AR | |
| SCHEMBL7092850 | 0.74 | SNCA (0.43) | ALDH1A1KDM4EMEN1KMT2AHTR2A | |
| SCHEMBL11371183 | 0.74 | ALDH1A1 (0.44) | ALDH1A1CYP1A2KDM4EHPGDHSD17B10 | |
| SCHEMBL9176307 | 0.71 | ALDH1A1 (0.45) | PGRALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL12629401 | 0.71 | PDK2 (0.41) | ALDH1A1HSD17B10ARMEN1KMT2A | |
| SCHEMBL1316216 | 0.71 | PDK2 (0.41) | ALDH1A1HSD17B10ARMEN1KMT2A | |
| SCHEMBL11514128 | 0.70 | OPRD1 (0.37) | ALDH1A1KDM4EHPGDHSD17B10AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109314-B2 | Fluorescent nucleotides | FUJI PHOTO FILM CO., LTD. (JP) | 2006-09-19 | — | — | US | disclosed |
| EP-1152008-B1 | Fluorescent nucleotides containing a cyanine, merocyanine or styryl dye for the detection of nucleic acid | FUJI PHOTO FILM CO LTD (JP) | 2005-02-09 | — | — | EP | disclosed |
| US-20020064782-A1 | Fluorescent nucleotides | SHINOKI HIROSHI (JP) | 2002-05-30 | — | — | US | disclosed |
| EP-1152008-A2 | Fluorescent nucleotides containing a cyanine, merocyanine or styryl dye for the detection of nucleic acid | FUJI PHOTO FILM CO., LTD. (JP) | 2001-11-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020064782-A1 | Fluorescent nucleotides | SLC35B2, SLC29A1, ATIC | PGR 3630/4885IDO1 4435/4885CYP46A1 4030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.