SCHEMBL603366

SCHEMBL603366

CCCCC(=CC=CC#N)c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 5/20 0.42
CES2 O00748 4/20 0.41
CES1 P23141 4/20 0.41
ESR1 P03372 1/20 0.38
ALDH1A1 P00352 1/20 0.35
TSHR P16473 1/20 0.35
PCSK9 Q8NBP7 1/20 0.33
HDAC3 O15379 1/20 0.33
HDAC4 P56524 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC7 Q8WUI4 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC10 Q969S8 1/20 0.33
HDAC11 Q96DB2 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
HDAC9 Q9UKV0 1/20 0.33
HDAC5 Q9UQL6 1/20 0.33
PTGS1 P23219 1/20 0.33
NAAA Q02083 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28643288 0.78 PTGS2 (0.45) PTGS2CES2CES1ESR1ALDH1A1
SCHEMBL2380962 0.78 KDM4E (0.48) PTGS2CES2CES1ESR1ALDH1A1
SCHEMBL9741942 0.78 ALDH1A1 (0.37) ALDH1A1HDAC3HDAC4HDAC1HDAC7
SCHEMBL272292 0.76 CES2 (0.51) PTGS2CES2CES1ESR1ALDH1A1
SCHEMBL28273252 0.76 PTGS2 (0.49) PTGS2CES2CES1ESR1ALDH1A1
SCHEMBL29131554 0.76 PTGS2 (0.49) PTGS2CES2CES1ESR1ALDH1A1
SCHEMBL7944718 0.75 PTGS2 (0.55) PTGS2CES2CES1ESR1ALDH1A1
SCHEMBL603161 0.72 HDAC3 (0.38) CES2CES1ALDH1A1TSHRHDAC3
SCHEMBL4822579 0.72 PTGS2 (0.52) PTGS2CES2CES1ESR1ALDH1A1
SCHEMBL27699487 0.72 PTGS2 (0.52) PTGS2CES2CES1ESR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE43173-E1 Helmet with in-mold and post-applied hard shell K-2 CORPORATION (US) 2012-02-14 US claimed
US-7475434-B2 Helmet with in-mold and post-applied hard shell K-2 CORPORATION (US) 2009-01-13 US claimed
EP-1689258-B1 HELMET WITH IN-MOLD AND POST-APPLIED HARD SHELL K 2 CORP (US) 2008-04-02 EP claimed
EP-1689258-A1 HELMET WITH IN-MOLD AND POST-APPLIED HARD SHELL K-2 CORPORATION (US) 2006-08-16 EP claimed
US-20050241049-A1 Helmet with in-mold and post-applied hard shell WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT 2005-11-03 US claimed
WO-2005055752-A1 HELMET WITH IN-MOLD AND POST-APPLIED HARD SHELL K-2 CORPORATION (US) 2005-06-23 WO claimed
US-9895590-B2 Method and system to analyze sports motions using motion sensors of a mobile device AQUIMO, LLC (US) 2018-02-20 US disclosed
US-20170021251-A1 USING A MOBILE DEVICE WITH INTEGRATED MOTION SENSING FOR CUSTOMIZED GOLF CLUB FITTING AQUIMO, LLC (US) 2017-01-26 US disclosed
US-9339707-B2 Using a mobile device with integrated motion sensing for customized golf club fitting AQUIMO, LLC (US) 2016-05-17 US disclosed
US-20150231477-A1 METHOD AND SYSTEM TO ANALYZE SPORTS MOTIONS USING MOTION SENSORS OF A MOBILE DEVICE THE NORTON FAMILY LIVING TRUST 2015-08-20 US disclosed
US-9101812-B2 Method and system to analyze sports motions using motion sensors of a mobile device AQUIMO, LLC (US) 2015-08-11 US disclosed
US-9050512-B2 2015-06-09 US disclosed
EP-2771081-A1 METHOD AND SYSTEM TO ANALYZE SPORTS MOTIONS USING MOTION SENSORS OF A MOBILE DEVICE AQUIMO, LLC (US) 2014-09-03 EP disclosed
EP-1689258-A1 HELMET WITH IN-MOLD AND POST-APPLIED HARD SHELL K-2 CORPORATION (US) 2006-08-16 EP disclosed
US-20050241049-A1 Helmet with in-mold and post-applied hard shell WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT 2005-11-03 US disclosed
WO-2005055752-A1 HELMET WITH IN-MOLD AND POST-APPLIED HARD SHELL K-2 CORPORATION (US) 2005-06-23 WO disclosed
EP-0600068-B1 THERMAL TRANSFER PRINTING RECEIVER SHEET AND METHOD ICI PLC (GB) 1997-08-13 EP disclosed
US-5430003-A Thermal transfer printing receiver sheet and method IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1995-07-04 US disclosed
EP-0600068-A1 THERMAL TRANSFER PRINTING RECEIVER SHEET AND METHOD. ICI PLC (GB) 1994-06-08 EP disclosed
WO-1993025392-A1 THERMAL TRANSFER PRINTING RECEIVER SHEET AND METHOD IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-12-23 WO disclosed