Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 8/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30618855 | 0.84 | LMNA (0.64) | HTTLMNAALDH1A1HPGDKMT2A | |
| SCHEMBL298766 | 0.84 | LMNA (0.64) | HTTLMNAALDH1A1HPGDKMT2A | |
| SCHEMBL31530440 | 0.83 | LMNA (0.48) | HTTLMNAALDH1A1HPGDKMT2A | |
| SCHEMBL11299077 | 0.83 | LMNA (0.48) | HTTLMNAALDH1A1HPGDKMT2A | |
| SCHEMBL643021 | 0.81 | LMNA (0.72) | HTTLMNAALDH1A1HPGDKMT2A | |
| SCHEMBL12516805 | 0.81 | ALDH1A1 (0.69) | HTTLMNAALDH1A1HPGDKMT2A | |
| SCHEMBL6033676 | 0.81 | LMNA (0.63) | HTTLMNAALDH1A1HPGDKMT2A | |
| SCHEMBL297297 | 0.80 | ALDH1A1 (0.48) | HTTLMNAALDH1A1HPGDKMT2A | |
| SCHEMBL18656991 | 0.79 | LMNA (0.45) | HTTLMNAALDH1A1HPGDKMT2A | |
| SCHEMBL10212063 | 0.77 | ALDH1A1 (0.46) | HTTLMNAALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230149911-A1 | RUTHENIUM-BASED METATHESIS CATALYSTS, PRECURSORS FOR THEIR PREPARATION AND THEIR USE | UMICORE AG & CO. KG (DE) | 2023-05-18 | — | — | US | disclosed |
| US-20230149911-A1 | RUTHENIUM-BASED METATHESIS CATALYSTS, PRECURSORS FOR THEIR PREPARATION AND THEIR USE | UMICORE AG & CO. KG (DE) | 2023-05-18 | — | — | US | disclosed |
| US-11577232-B2 | Ruthenium-based metathesis catalysts, precursors for their preparation and their use | UMICORE AG & CO. KG (DE) | 2023-02-14 | — | — | US | disclosed |
| US-20220118434-A1 | RUTHENIUM-BASED METATHESIS CATALYSTS, PRECURSORS FOR THEIR PREPARATION AND THEIR USE | UMICORE AG & CO. KG (DE) | 2022-04-21 | — | — | US | disclosed |
| US-11241680-B2 | Ruthenium-based metathesis catalysts, precursors for their preparation and their use | UMICORE AG & CO. KG | 2022-02-08 | — | — | US | disclosed |
| EP-2912048-B1 | RUTHENIUM-BASED METATHESIS CATALYSTS, PRECURSORS FOR THEIR PREPARATION AND THEIR USE | UMICORE AG & CO KG (DE) | 2017-07-19 | — | — | EP | disclosed |
| US-20150266009-A1 | RUTHENIUM-BASED METATHESIS CATALYSTS, PRECURSORS FOR THEIR PREPARATION AND THEIR USE | UMICORE AG & CO KG (DE) | 2015-09-24 | — | — | US | disclosed |
| US-20150266009-A1 | RUTHENIUM-BASED METATHESIS CATALYSTS, PRECURSORS FOR THEIR PREPARATION AND THEIR USE | UMICORE AG & CO KG (DE) | 2015-09-24 | — | — | US | disclosed |
| WO-2014067767-A1 | RUTHENIUM-BASED METATHESIS CATALYSTS, PRECURSORS FOR THEIR PREPARATION AND THEIR USE | UMICORE AG & CO. KG (DE) | 2014-05-08 | — | — | WO | disclosed |
| EP-2725030-A1 | Ruthenium-based metathesis catalysts, precursors for their preparation and their use | Umicore AG & Co. KG (DE) | 2014-04-30 | — | — | EP | disclosed |
| CN-1882375-A | treatment of amyloid-and epileptogenesis-related diseases | NEUROCHEM INTERNAT LTD (CH) | 2006-12-20 | — | — | CN | disclosed |
| EP-1635909-A2 | TREATMENT OF AMYLOID- AND EPILEPTOGENESIS-ASSOCIATED DISEASES | Neurochem (International) Limited (CH) | 2006-03-22 | — | — | EP | disclosed |
| US-20050038000-A1 | Methods and compositions for the treatment of amyloid-and epileptogenesis-associated diseases | BELLUS HEALTH (INTERNATIONAL) LIMITED (CH) | 2005-02-17 | — | — | US | disclosed |
| WO-2005000406-A2 | TREATMENT OF AMYLOID- AND EPILEPTOGENESIS-ASSOCIATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2005-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11241680-B2 | Ruthenium-based metathesis catalysts, precursors for their preparation and their use | HMBS, RRP12, RNF168 | HTT 1091/4885LMNA 4812/4885ALDH1A1 844/4885 |
| US-20230149911-A1 | RUTHENIUM-BASED METATHESIS CATALYSTS, PRECURSORS FOR THEIR PREPARATION AND THEIR USE | HMBS, RRP12, RNF168 | HTT 1091/4885LMNA 4812/4885ALDH1A1 844/4885 |
| US-11577232-B2 | Ruthenium-based metathesis catalysts, precursors for their preparation and their use | HMBS, RRP12, RNF168 | HTT 1091/4885LMNA 4812/4885ALDH1A1 844/4885 |
| US-20220118434-A1 | RUTHENIUM-BASED METATHESIS CATALYSTS, PRECURSORS FOR THEIR PREPARATION AND THEIR USE | HMBS, RRP12, RNF168 | HTT 1091/4885LMNA 4812/4885ALDH1A1 844/4885 |
| US-20050038000-A1 | Methods and compositions for the treatment of amyloid-and epileptogenesis-associated diseases | APP, PSEN1, PSEN2 | HTT 91/4885LMNA 1292/4885ALDH1A1 1493/4885 |
| US-20150266009-A1 | RUTHENIUM-BASED METATHESIS CATALYSTS, PRECURSORS FOR THEIR PREPARATION AND THEIR USE | HMBS, RRP12, RNF168 | HTT 1091/4885LMNA 4812/4885ALDH1A1 844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.