SCHEMBL604236

SCHEMBL604236

Nc1ccc(OC(F)(F)F)cc1Br

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 5/20 0.44
GAA P10253 2/20 0.44
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
GMNN O75496 1/20 0.44
USP2 O75604 1/20 0.44
LMNA P02545 1/20 0.44
TP53 P04637 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
ADORA3 P0DMS8 1/20 0.44
CYP2C9 P11712 1/20 0.44
PKM P14618 1/20 0.44
ALOX15 P16050 1/20 0.44
NFKB1 P19838 1/20 0.44
SLC6A2 P23975 1/20 0.44
SCN4A P35499 1/20 0.44
BLM P54132 1/20 0.44
PMP22 Q01453 1/20 0.44
SLC6A3 Q01959 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1034163 0.84 GPR3 (0.44) GPR3GAANPC1RAB9AGMNN
SCHEMBL23505696 0.82 ALDH1A1 (0.38) GAANPC1RAB9AGMNNUSP2
SCHEMBL442684 0.81 NR4A1 (0.56) GPR3GAANPC1RAB9AGMNN
SCHEMBL29546263 0.81 NR4A1 (0.56) GPR3GAANPC1RAB9AGMNN
SCHEMBL29382481 0.80 CYP3A4 (0.45) GPR3GAANPC1RAB9AGMNN
SCHEMBL1039855 0.80 CYP3A4 (0.45) GPR3GAANPC1RAB9AGMNN
Hydrochloric Acid SCHEMBL9526864 0.79 NR4A1 (0.54) GPR3GAANPC1RAB9AGMNN
SCHEMBL15718212 0.78 GPR3 (0.46) GPR3GAANPC1RAB9AGMNN
SCHEMBL30018924 0.78 GPR3 (0.46) GPR3GAANPC1RAB9AGMNN
SCHEMBL519232 0.78 ALDH1A1 (0.46) GPR3GAANPC1RAB9AGMNN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 245 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115974705-A Preparation method of 2-bromo-4-trifluoromethoxyaniline 阜新睿光氟化学有限公司 2023-04-18 CN claimed
WO-2005100434-A1 HALOGEN CONTAINING EPOXY COMPOSITIONS AND THEIR PREPARATION UNIVERSITY OF NORTH TEXAS (US) 2005-10-27 WO claimed
US-20050228080-A1 Halogen containing epoxy compositions and their preparation UNIVERSITY OF NORTH TEXAS (US) 2005-10-13 US claimed
EP-3601235-B1 BICYCLIC HETEROARYL DERIVATIVES, PREPARATION AND THERAPEUTIC USES THEREOF XWPHARMA LTD (KY) 2026-03-04 EP disclosed
US-20260035348-A1 PHENYL-N-QUINOLINE DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2026-02-05 US disclosed
US-20250368647-A1 NITROGEN CONTAINING CONDENSED 2,3-DIHYDROQUINAZOLINONE COMPOUNDS AS NAV1.8 INHIBITORS GLAXOSMITHKLINE IP DEV LTD (GB) 2025-12-04 US disclosed
US-12479802-B2 Phenyl-n-quinoline derivatives for treating a RNA virus infection ABIVAX (FR) 2025-11-25 US disclosed
EP-4536660-A1 NITROGEN CONTAINING CONDENSED 2,3-DIHYDROQUINAZOLINONE COMPOUNDS AS NAV1.8 INHIBITORS GlaxoSmithKline Intellectual Property Development Ltd (GB) 2025-04-16 EP disclosed
CN-119462748-A Preparation method of fluorine-containing carbazole phosphonic acid compound 浙江科技大学 2025-02-18 CN disclosed
US-20250034122-A1 SUBSTITUTED N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS MISSION THERAPEUTICS LIMITED (GB) 2025-01-30 US disclosed
CN-119325476-A Nitrogen-containing condensed 2, 3-dihydroquinazolinone compounds as NAV1.8 inhibitors 葛兰素史密斯克莱知识产权发展有限公司 2025-01-17 CN disclosed
CN-1379755-A Substituted 2-Dialkylaminoalkylbiphenyl Derivatives GRUENTHAL GMBH (DE) 2002-11-13 CN disclosed
WO-2002078693-A2 N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR ELI LILLY AND COMPANY (US) 2002-10-10 WO disclosed
US-20020147212-A1 Azabicyclic amine derivatives and their use as therapeutic agents MERCK SHARP & DOHME LTD. (GB) 2002-10-10 US disclosed
CN-1356977-A Glucagon antagonists/inverse agonists NOVO NORDISK AS (DK) 2002-07-03 CN disclosed
EP-1183229-A1 GLUCAGON ANTAGONISTS/INVERSE AGONISTS NOVO NORDISK A/S (DK) 2002-03-06 EP disclosed
WO-2000069810-A1 GLUCAGON ANTAGONISTS/INVERSE AGONISTS NOVO NORDISK A/S (DK) 2000-11-23 WO disclosed
EP-1045833-A1 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS PFIZER INC. (US) 2000-10-25 EP disclosed
US-6071927-A Spiro-piperidine derivatives and their use as therapeutic agents MERCK SHARP & DOHME LTD. (GB) 2000-06-06 US disclosed
WO-1999035130-A1 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS PFIZER PHARMACEUTICALS INC. (JP) 1999-07-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020147212-A1 Azabicyclic amine derivatives and their use as therapeutic agents CXCR1, CXCR6, CCR6 GPR3 268/4885GAA 1432/4885NPC1 1604/4885
US-20250034122-A1 SUBSTITUTED N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS USP30, USP47, USP1 GPR3 3832/4885GAA 3398/4885NPC1 1789/4885
US-20250368647-A1 NITROGEN CONTAINING CONDENSED 2,3-DIHYDROQUINAZOLINONE COMPOUNDS AS NAV1.8 INHIBITORS SCN8A, SCN2A, SCN5A GPR3 1402/4885GAA 3944/4885NPC1 839/4885
US-20260035348-A1 PHENYL-N-QUINOLINE DERIVATIVES FOR TREATING A RNA VIRUS INFECTION SARS1, NDUFC2, CLIC1 GPR3 3196/4885GAA 2985/4885NPC1 174/4885
US-12479802-B2 Phenyl-n-quinoline derivatives for treating a RNA virus infection ORC3, NSUN3, POLR2H GPR3 339/4885GAA 2692/4885NPC1 654/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.