Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TACR3 | P29371 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | NMBR | P28336 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL837439 | 0.85 | HTT (0.35) | KDM4EMAPTL3MBTL1TACR3ALDH1A1 | |
| SCHEMBL837267 | 0.85 | NR4A2 (0.39) | KDM4EMAPTL3MBTL1TACR1ALDH1A1 | |
| SCHEMBL837254 | 0.85 | MPO (0.40) | KDM4EMAPTL3MBTL1TACR1ALDH1A1 | |
| SCHEMBL837920 | 0.84 | MTNR1A (0.45) | KDM4EMAPTL3MBTL1TACR1ALDH1A1 | |
| SCHEMBL838321 | 0.80 | PKM (0.55) | KDM4EMAPTKMT2AMEN1PKM | |
| SCHEMBL837467 | 0.76 | SPR (0.30) | — | |
| SCHEMBL4234106 | 0.74 | GPR84 (0.39) | KDM4EMAPTPOLBRECQLKMT2A | |
| SCHEMBL4240366 | 0.74 | GPR84 (0.37) | KDM4EMAPTPOLBRECQLKMT2A | |
| SCHEMBL4236247 | 0.72 | ALDH1A1 (0.34) | KDM4EMAPTPOLBRECQLKMT2A | |
| SCHEMBL8706227 | 0.70 | KDM4E (0.54) | KDM4EMAPTPOLBL3MBTL1APAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663184-A2 | HYDANTOIN DERIVATIVES AS INHIBITORS OF CELLULAR NECROSIS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005077344-A2 | HYDANTOIN DERIVATIVES AS INHIBITORS OF CELLULAR NECROSIS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2005-08-25 | — | — | WO | disclosed |