SCHEMBL6045753

SCHEMBL6045753

O=C(O)c1cc(Cl)c2c(c1Cl)C1(OC2=O)c2cc(Cl)c(O)cc2Oc2cc(O)c(-c3ccccc3)cc21

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.47
HPGD P15428 3/20 0.43
BRCA1 P38398 2/20 0.43
HSD17B10 Q99714 2/20 0.43
CYP2C9 P11712 1/20 0.43
ALOX15 P16050 1/20 0.43
ALOX12 P18054 1/20 0.43
SMAD3 P84022 2/20 0.38
FTO Q9C0B1 3/20 0.35
GPR35 Q9HC97 1/20 0.35
HNF4A P41235 1/20 0.34
RECQL P46063 3/20 0.34
TDP1 Q9NUW8 3/20 0.34
THRB P10828 2/20 0.34
MEN1 O00255 2/20 0.34
BLM P54132 2/20 0.34
KMT2A Q03164 2/20 0.34
DHFR P00374 2/20 0.34
TYMS P04818 2/20 0.34
CYP3A4 P08684 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL235829 0.92 SMAD3 (0.40) ALDH1A1HPGDBRCA1HSD17B10CYP2C9
SCHEMBL29461682 0.92 SMAD3 (0.40) ALDH1A1HPGDBRCA1HSD17B10CYP2C9
Cyanide SCHEMBL6533545 0.89 SMAD3 (0.38) ALDH1A1HPGDBRCA1HSD17B10CYP2C9
SCHEMBL1022908 0.83 SMAD3 (0.40) ALDH1A1HPGDBRCA1HSD17B10CYP2C9
SCHEMBL231207 0.80 ALDH1A1 (0.58) ALDH1A1HPGDBRCA1HSD17B10CYP2C9
SCHEMBL6816059 0.80 SMAD3 (0.36) ALDH1A1HPGDBRCA1HSD17B10CYP2C9
SCHEMBL13252809 0.79 SMAD3 (0.36) ALDH1A1HPGDBRCA1HSD17B10CYP2C9
SCHEMBL6819303 0.79 ALDH1A1 (0.39) ALDH1A1HPGDBRCA1HSD17B10CYP2C9
SCHEMBL1468956 0.78 ALDH1A1 (0.40) ALDH1A1HPGDBRCA1HSD17B10CYP2C9
SCHEMBL29838734 0.77 SMAD3 (0.35) ALDH1A1HPGDBRCA1HSD17B10CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 144 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024148174-A1 PEPTIDE SEQUENCER OREGON HEALTH & SCIENCE UNIVERSITY (US) 2024-07-11 WO disclosed
US-12033724-B2 Methods for simultaneous pooled genotyping PIONEER HI-BRED INTERNATIONAL, INC. (US) 2024-07-09 US disclosed
WO-2024129991-A1 METHODS FOR PRODUCING SOYBEAN WITH ALTERED COMPOSITION PIONEER HI-BRED INTERNATIONAL, INC. (US) 2024-06-20 WO disclosed
WO-2024119614-A1 NOVEL MICROBIAL MARKER FOR PREDICTING RISK OF COLORECTAL CANCER 臻傲生物科技检测(深圳)有限公司 2024-06-13 WO disclosed
CN-118086027-A Digital PCR chip and signal processing method thereof 上海市嘉定区南翔医院 2024-05-28 CN disclosed
WO-2024076897-A2 METHODS FOR PRODUCING HIGH PROTEIN SOYBEANS PIONEER HI-BRED INTERNATIONAL, INC. (US) 2024-04-11 WO disclosed
US-11939573-B2 Methods and compositions for nucleic acid analysis BIO-RAD LABORATORIES, INC. (US) 2024-03-26 US disclosed
US-20230287486-A1 ANALYSIS OF NUCLEIC ACIDS BIO-RAD LABORATORIES, INC. (US) 2023-09-14 US disclosed
WO-2023157007-A1 KITS AND METHODS FOR SELECTING EUCALYPTUS GENOTYPES RESISTANT TO PHYSIOLOGICAL DISTURBANCE FUTURAGENE ISRAEL LTD. (IL) 2023-08-24 WO disclosed
EP-3504346-B1 FECAL BACTERIAL MARKERS FOR COLORECTAL CANCER UNIV HONG KONG CHINESE (HK) 2023-08-16 EP disclosed
WO-2012092461-A2 METHODS OF IDENTIFYING APHID RESISTANT SOYBEANS PIONEER HI-BRED INTERNATIONAL, INC. (US) 2012-07-05 WO disclosed
US-20120145092-A1 Identification of the causative mutation for leopard complex spotting & congenital stationary night blindness in equines and a method for testing for same UNIVERSITY OF SASKATCHEWAN (CA) 2012-06-14 US disclosed
US-7759126-B2 Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for amplification (or PCR) analysis ELITECH HOLDING B.V. (NL) 2010-07-20 US disclosed
US-7759126-B2 Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for amplification (or PCR) analysis ELITECH HOLDING B.V. (NL) 2010-07-20 US disclosed
US-7381818-B2 Fluorescent probes containing 5′-minor groove binder, fluorophore and quenching moieties and methods of use thereof EPOCH BIOSCIENCES, INC. (US) 2008-06-03 US disclosed
US-7381818-B2 Fluorescent probes containing 5′-minor groove binder, fluorophore and quenching moieties and methods of use thereof EPOCH BIOSCIENCES, INC. (US) 2008-06-03 US disclosed
US-20060263794-A1 METHODS FOR DETECTING TARGET NUCLEIC ACIDS USING COUPLED LIGATION AND AMPLIFICATION APPLERA CORPORATION (US) 2006-11-23 US disclosed
US-20030190646-A1 Methods for detecting target nucleic acids using coupled ligation and amplification APPLIED BIOSYSTEMS, LLC 2003-10-09 US disclosed
EP-1313880-A2 METHODS FOR DETECTING TARGET NUCLEIC ACIDS USING COUPLED LIGATION AND AMPLIFICATION PE Corporation (NY) (US) 2003-05-28 EP disclosed
WO-2001092579-A2 METHODS FOR DETECTING TARGET NUCLEIC ACIDS USING COUPLED LIGATION AND AMPLIFICATION PE CORPORATION (NY) (US) 2001-12-06 WO disclosed