Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11767335 | 0.85 | MAOA (0.50) | ALDH1A1NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL6046510 | 0.80 | MAPT (0.49) | ALDH1A1SIRT2NPC1MAPK13MAPK12 | |
| SCHEMBL7260939 | 0.79 | DRD2 (0.49) | FFAR1KEAP1FFAR4KDM4EMAPT | |
| SCHEMBL4551283 | 0.79 | SMYD3 (0.50) | FFAR1MAOB | |
| SCHEMBL30263704 | 0.77 | RXRA (0.57) | ALDH1A1FFAR1KEAP1FFAR4 | |
| SCHEMBL20680969 | 0.77 | RXRA (0.57) | ALDH1A1FFAR1KEAP1FFAR4 | |
| SCHEMBL7392253 | 0.77 | KDM4E (0.57) | ALDH1A1FFAR1KDM4EGAAMAPT | |
| SCHEMBL1294298 | 0.77 | MAOB (0.50) | FFAR1NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL6046439 | 0.76 | SIRT2 (0.48) | ALDH1A1CYP1A2SIRT2MAPK1NPC1 | |
| SCHEMBL6046472 | 0.75 | SIRT2 (0.63) | ALDH1A1SIRT2NPC1MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060252679-A1 | Preventive and/or trerapeutic drgs for itch | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252679-A1 | Preventive and/or trerapeutic drgs for itch | GPR4, TRPV1, TRPV4 | ALDH1A1 2351/4885CYP1A2 4588/4885FFAR1 198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.