SCHEMBL6046930

SCHEMBL6046930

COc1ccc(C(=O)Nc2ccn(CC(=O)N(CCNC(=O)OC(C)(C)C)CC(=O)O)c(=O)n2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.42
ADORA3 P0DMS8 3/20 0.36
CKS1B P61024 1/20 0.36
SKP1 P63208 1/20 0.36
SKP2 Q13309 1/20 0.36
NPC1 O15118 3/20 0.36
RAB9A P51151 3/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
TP53 P04637 1/20 0.36
NFKB1 P19838 1/20 0.36
NFKB2 Q00653 1/20 0.36
RELA Q04206 1/20 0.36
MEN1 O00255 3/20 0.35
KMT2A Q03164 3/20 0.35
ALDH1A1 P00352 1/20 0.35
F2 P00734 1/20 0.35
DEGS1 O15121 2/20 0.35
BRD4 O60885 1/20 0.34
SUV39H2 Q9H5I1 3/20 0.34
KDM4E B2RXH2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3731633 0.92 MAPT (0.45) MAPTCKS1BSKP1SKP2RAB9A
SCHEMBL7717128 0.89 ABL1 (0.40) MAPTADORA3CKS1BSKP1SKP2
SCHEMBL8645940 0.87 MAPT (0.43) MAPTCKS1BSKP1SKP2RAB9A
SCHEMBL3670409 0.82 RAB9A (0.47) MAPTCKS1BSKP1SKP2RAB9A
SCHEMBL15234703 0.80 CKS1B (0.42) MAPTADORA3CKS1BSKP1SKP2
SCHEMBL7263673 0.79 FPR2 (0.47) MAPTADORA3NPC1RAB9ASMN1; SMN2
SCHEMBL6046940 0.79 HDAC1 (0.43) ADORA3CKS1BSKP1SKP2BRD4
SCHEMBL7528362 0.78 ADORA3 (0.51) MAPTADORA3NPC1RAB9ASMN1; SMN2
SCHEMBL14308496 0.76 KMT2A (0.41) MAPTCKS1BSKP1SKP2RAB9A
SCHEMBL7874477 0.71 MAPT (0.48) MAPTNPC1RAB9AMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1105525-B1 A PROCESS FOR PREPARING PEPTIDE NUCLEIC ACID PROBE USING POLYMERIC PHOTOACID GENERATOR SAMSUNG ELECTRONICS CO LTD (KR) 2006-11-02 EP disclosed
US-6660479-B2 Derivatizing surface of a solid matrix and attaching linker with acid- labile protecting group on solid matrix; coating solid matrix with polymeric photoacid generator(PAG); exposing solid matrix thus coated to light to generate acid; reacting SAMSUNG ELECTRONICS CO., LTD. (KR) 2003-12-09 US disclosed
US-20020122874-A1 Process for preparing peptide nucleic acid probe using polymeric photoacid generator SAMSUNG ELECTRONICS CO., LTD. (KR) 2002-09-05 US disclosed
US-6359125-B1 DERIVATIZING SURFACE OF SOLID MATRIX WITH AMINOALKYLOXYSILANE AND ATTACHING LINKER WITH ACID-LABILE PROTECTING GROUP TO AMINE GROUP ON MATRIX, COATING MATRIX WITH POLYMERIC PHOTOACID GENERATOR, EXPOSING TO LIGHT, ATTACHING PEPTIDE NUCLEIC ACID SAMSUNG ELECTRONICS CO., LTD. (KR) 2002-03-19 US disclosed