Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 16/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.40 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6570571 | 0.95 | RIPK1 (0.39) | RIPK1FKBP1AMTORFKBP4FKBP5 | |
| SCHEMBL7429151 | 0.85 | FKBP1A (0.47) | FKBP1AMTORFKBP4FKBP5 | |
| SCHEMBL7771830 | 0.82 | FKBP1A (0.49) | FKBP1AMTORFKBP4FKBP5 | |
| SCHEMBL6570600 | 0.81 | FKBP1A (0.47) | FKBP1AMTORFKBP4FKBP5 | |
| SCHEMBL7433188 | 0.75 | FKBP1A (0.59) | FKBP1AMTORFKBP4FKBP5 | |
| SCHEMBL7422008 | 0.74 | FKBP1A (0.61) | FKBP1AMTORFKBP4FKBP5 | |
| SCHEMBL4677127 | 0.73 | FKBP1A (0.66) | FKBP1AMTORFKBP4FKBP5 | |
| SCHEMBL17881986 | 0.70 | RIPK1 (0.80) | RIPK1 | |
| SCHEMBL5700677 | 0.70 | FKBP1A (0.49) | FKBP1AMTORFKBP4FKBP5 | |
| SCHEMBL5700673 | 0.70 | FKBP1A (0.44) | RIPK1FKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934263-B8 | NON-IMMUNOSUPPRESSANT FKBP ROTAMASE INHIBITORS | MGI GP INC (US) | 2006-01-18 | — | — | EP | claimed |
| EP-0934263-A4 | HETEROCYCLIC THIOESTERS AND KETONES | GUILFORD PHARM INC (US) | 2002-11-06 | — | — | EP | claimed |
| JP-2002516844-A | — | — | 2002-06-11 | — | — | JP | claimed |
| EP-1104298-A2 | HETEROCYCLIC THIOESTERS OR KETONES FOR VISION AND MEMORY DISORDERS | GPI NIL Holdings, Inc. (US) | 2001-06-06 | — | — | EP | claimed |
| JP-2001506231-A | — | — | 2001-05-15 | — | — | JP | claimed |
| EP-1083873-A1 | HETEROCYCLIC THIOESTER AND KETONE HAIR GROWTH COMPOSITIONS AND USES | GPI NIL Holdings, Inc. (US) | 2001-03-21 | — | — | EP | claimed |
| WO-2000009479-A2 | HETEROCYCLIC THIOESTERS OR KETONES FOR VISION AND MEMORY DISORDERS | GPI NIL HOLDINGS, INC. (US) | 2000-02-24 | — | — | WO | claimed |
| WO-1999062488-A1 | HETEROCYCLIC THIOESTER AND KETONE HAIR GROWTH COMPOSITIONS AND USES | GPI NIL HOLDINGS, INC. (US) | 1999-12-09 | — | — | WO | claimed |
| EP-0934263-A1 | HETEROCYCLIC THIOESTERS AND KETONES | GUILFORD PHARMACEUTICALS INC. (US) | 1999-08-11 | — | — | EP | claimed |
| WO-1998013343-A1 | HETEROCYCLIC THIOESTERS AND KETONES | GUILFORD PHARMACEUTICALS INC. (US) | 1998-04-02 | — | — | WO | claimed |
| EP-1127049-A1 | BRIDGED HETEROCYCLIC DERIVATIVES | GPI NIL Holdings, Inc. (US) | 2001-08-29 | — | — | EP | disclosed |
| EP-1011650-A1 | METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS | Amgen Inc., (US) | 2000-06-28 | — | — | EP | disclosed |
| WO-2000016603-A2 | BRIDGED HETEROCYCLIC DERIVATIVES | GPI NIL HOLDINGS, INC. (US) | 2000-03-30 | — | — | WO | disclosed |
| WO-1999014998-A2 | METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS | AMGEN INC. (US) | 1999-04-01 | — | — | WO | disclosed |