SCHEMBL7433188

SCHEMBL7433188

CCCOC(=O)C1C(c2cccnc2)CCCN1C(=O)C(=O)C(C)(C)CC

nearest known ligand 0.59

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FKBP1A P62942 18/20 0.59
MTOR P42345 1/20 0.59
FKBP4 Q02790 1/20 0.59
FKBP5 Q13451 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7426919 0.84 FKBP1A (0.53) FKBP1AMTORFKBP4FKBP5
SCHEMBL7422008 0.79 FKBP1A (0.61) FKBP1AMTORFKBP4FKBP5
SCHEMBL5376185 0.78 FKBP1A (0.49) FKBP1AMTORFKBP4FKBP5
SCHEMBL7424334 0.76 FKBP1A (0.64) FKBP1AMTORFKBP4FKBP5
SCHEMBL6049183 0.75 RIPK1 (0.44) FKBP1AMTORFKBP4FKBP5
Gpi-1046 SCHEMBL4766380 0.74 FKBP1A (1.00) FKBP1AMTORFKBP4FKBP5
Gpi-1046 SCHEMBL7187 0.74 FKBP1A (1.00) FKBP1AMTORFKBP4FKBP5
SCHEMBL5372501 0.74 FKBP1A (0.46) FKBP1AMTORFKBP4FKBP5
Gpi-1046 SCHEMBL7324245 0.74 FKBP1A (0.98) FKBP1AMTORFKBP4FKBP5
Gpi-1046 SCHEMBL2191097 0.74 FKBP1A (0.98) FKBP1AMTORFKBP4FKBP5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2002522485-A 2002-07-23 JP claimed
EP-1109554-A2 PIPECOLIC ACID DERIVATIVES FOR VISION AND MEMORY DISORDERS GPI NIL Holdings, Inc. (US) 2001-06-27 EP claimed
WO-2000009109-A2 PIPECOLIC ACID DERIVATIVES FOR VISION AND MEMORY DISORDERS GPI NIL HOLDINGS, INC. (US) 2000-02-24 WO claimed
EP-1127049-A1 BRIDGED HETEROCYCLIC DERIVATIVES GPI NIL Holdings, Inc. (US) 2001-08-29 EP disclosed
EP-1109554-A2 PIPECOLIC ACID DERIVATIVES FOR VISION AND MEMORY DISORDERS GPI NIL Holdings, Inc. (US) 2001-06-27 EP disclosed
WO-2000016603-A2 BRIDGED HETEROCYCLIC DERIVATIVES GPI NIL HOLDINGS, INC. (US) 2000-03-30 WO disclosed
WO-2000009109-A2 PIPECOLIC ACID DERIVATIVES FOR VISION AND MEMORY DISORDERS GPI NIL HOLDINGS, INC. (US) 2000-02-24 WO disclosed