Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 8/20 | 0.50 |
| ▸ | CES1 | P23141 | 7/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16044915 | 0.86 | MAPT (0.45) | CES2CES1MAPTLMNAXBP1 | |
| SCHEMBL6830394 | 0.84 | LMNA (0.44) | CES2CES1MAPTLMNAXBP1 | |
| SCHEMBL10979998 | 0.83 | GPR139 (0.42) | CES2CES1MAPTLMNAXBP1 | |
| SCHEMBL7546809 | 0.83 | SMN1; SMN2 (0.44) | CES2CES1MAPTLMNAXBP1 | |
| SCHEMBL6575624 | 0.83 | SMN1; SMN2 (0.44) | CES2CES1MAPTLMNAXBP1 | |
| SCHEMBL6578239 | 0.83 | SMN1; SMN2 (0.44) | CES2CES1MAPTLMNAXBP1 | |
| SCHEMBL16250754 | 0.81 | GPR139 (0.45) | CES2CES1MAPTLMNAXBP1 | |
| Hydrochloric Acid SCHEMBL11106436 | 0.81 | SMN1; SMN2 (0.42) | CES2CES1MAPTLMNAXBP1 | |
| SCHEMBL16236134 | 0.81 | GPR139 (0.45) | CES2CES1MAPTLMNAXBP1 | |
| SCHEMBL27838181 | 0.81 | GPR139 (0.49) | CES2CES1MAPTLMNAXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118749013-A | Resin composition, cured product, electronic component, and display device | 东丽株式会社 | 2024-10-08 | — | — | CN | disclosed |
| US-11753436-B2 | Analogs of celastrol | ERX PHARMACEUTICALS CORPORATION (US) | 2023-09-12 | — | — | US | disclosed |
| US-11753436-B2 | Analogs of celastrol | ERX PHARMACEUTICALS CORPORATION (US) | 2023-09-12 | — | — | US | disclosed |
| US-11331317-B2 | Composition for treating vascular or cardiac valvular calcification, containing thiamine derivative | KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) | 2022-05-17 | — | — | US | disclosed |
| US-20210290621-A1 | COMPOSITION FOR PREVENTING OR TREATING VASCULAR OR CARDIAC VALVULAR CALCIFICATION, CONTAINING THIAMINE DERIVATIVE | PRIMEMUPHARMA CO., LTD (KR) | 2021-09-23 | — | — | US | disclosed |
| US-20210061851-A1 | ANALOGS OF CELASTROL | ERX PHARMACEUTICALS CORPORATION | 2021-03-04 | — | — | US | disclosed |
| US-10662218-B2 | Analogs of celastrol | ERX PHARMACEUTICALS CORPORATION | 2020-05-26 | — | — | US | disclosed |
| US-10179175-B2 | Isatoic anhydride derivatives and applications thereof | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE (US) | 2019-01-15 | — | — | US | disclosed |
| US-20180110862-A1 | ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE | 2018-04-26 | — | — | US | disclosed |
| US-20180110862-A1 | ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE | 2018-04-26 | — | — | US | disclosed |
| WO-2001051527-A1 | PROCATALYSTS, CATALYST SYSTEMS, AND USE IN OLEFIN POLYMERIZATION | EASTMAN CHEMICAL COMPANY (US) | 2001-07-19 | — | — | WO | disclosed |
| WO-2001051526-A1 | PROCATALYSTS COMPRISING BIDENTATE LIGANDS, CATALYST SYSTEMS, AND USE IN OLEFIN POLYMERIZATION | EASTMAN CHEMICAL COMPANY (US) | 2001-07-19 | — | — | WO | disclosed |
| WO-2001051529-A1 | PROCATALYSTS COMPRISING BIDENTATE LIGANDS, CATALYST SYSTEMS, AND USE IN OLEFIN POLYMERIZATION | EASTMAN CHEMICAL COMPANY (US) | 2001-07-19 | — | — | WO | disclosed |
| WO-2000075202-A1 | PROCESS FOR PRODUCING ETHYLENE/OLEFIN INTERPOLYMERS | EASTMAN CHEMICAL COMPANY (US) | 2000-12-14 | — | — | WO | disclosed |
| WO-2000075203-A1 | PROCESS FOR PRODUCING ETHYLENE/OLEFIN INTERPOLYMERS | EASTMAN CHEMICAL COMPANY (US) | 2000-12-14 | — | — | WO | disclosed |
| WO-2000075204-A1 | PROCESS FOR PRODUCING ETHYLENE/OLEFIN INTERPOLYMERS | EASTMAN CHEMICAL COMPANY (US) | 2000-12-14 | — | — | WO | disclosed |
| WO-2000052068-A1 | PROCESS FOR PRODUCING POLYETHYLENE | EASTMAN CHEMICAL COMPANY (US) | 2000-09-08 | — | — | WO | disclosed |
| CN-1039771-C | Sulfonylureas compounds | NOVATIS CO (CH) | 1998-09-16 | — | — | CN | disclosed |
| CN-1063490-A | SULFONYLUREAS COMPOUNDS | CIBA GEIGY AG (CH) | 1992-08-12 | — | — | CN | disclosed |
| CN-1059446-A | Synergism goods and the method for Selective Control weeds | CIBA GEIGY AG (CH) | 1992-03-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10179175-B2 | Isatoic anhydride derivatives and applications thereof | AASDHPPT, CA13, CA12 | CES2 1153/4885CES1 1925/4885MAPT 4720/4885 |
| US-20210061851-A1 | ANALOGS OF CELASTROL | GIPR, GPR119, EBP | CES2 125/4885CES1 27/4885MAPT 4052/4885 |
| US-20210290621-A1 | COMPOSITION FOR PREVENTING OR TREATING VASCULAR OR CARDIAC VALVULAR CALCIFICATION, CONTAINING THIAMINE DERIVATIVE | SLC19A2, FABP3, SLC5A6 | CES2 4308/4885CES1 1699/4885MAPT 2307/4885 |
| US-11331317-B2 | Composition for treating vascular or cardiac valvular calcification, containing thiamine derivative | SLC19A2, VDR, SLC5A6 | CES2 4468/4885CES1 1972/4885MAPT 2241/4885 |
| US-20180110862-A1 | ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF | AASDHPPT, CA13, CA12 | CES2 1153/4885CES1 1925/4885MAPT 4720/4885 |
| US-10662218-B2 | Analogs of celastrol | GIPR, GPR119, EBP | CES2 125/4885CES1 27/4885MAPT 4052/4885 |
| US-11753436-B2 | Analogs of celastrol | GIPR, GPR119, EBP | CES2 125/4885CES1 27/4885MAPT 4052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.