Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 1/20 | 0.49 |
| ▸ | F7 | P08709 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F9 | P00740 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | PLAT | P00750 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.44 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6061845 | 0.81 | RHEB (0.50) | RHEBF7CHEK2PKN1PKN2 | |
| SCHEMBL6505960 | 0.81 | RHEB (0.44) | RHEBF7CHEK2PKN1PKN2 | |
| SCHEMBL6061802 | 0.79 | RHEB (0.57) | RHEBCHEK2PKN1PKN2DGAT1 | |
| SCHEMBL8412123 | 0.79 | RHEB (0.59) | RHEBCHEK2PKN1PKN2DGAT1 | |
| SCHEMBL5428770 | 0.78 | RHEB (0.52) | RHEBCHEK2PKN1PKN2DGAT1 | |
| SCHEMBL22955340 | 0.78 | MAPK10 (0.52) | RHEBCHEK2PKN1PKN2METAP2 | |
| SCHEMBL6513301 | 0.77 | RHEB (0.44) | RHEBF7F2F10PLG | |
| SCHEMBL2313456 | 0.77 | MAPK10 (0.46) | RHEBCHEK2PKN1PKN2METAP2 | |
| SCHEMBL2308879 | 0.76 | METAP2 (0.43) | RHEBF7CHEK2PKN1PKN2 | |
| SCHEMBL2308883 | 0.76 | METAP2 (0.43) | RHEBF7CHEK2PKN1PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682518-A1 | DICATIONIC TRIARYL ANALOGS AS ANTI-PROTOZOAN AGENTS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2006-07-26 | — | — | EP | disclosed |
| US-20050148646-A1 | Dicationic triaryl analogs as anti-protozoan agents | BOYKIN DAVID W (US) | 2005-07-07 | — | — | US | disclosed |
| WO-2005040132-A1 | DICATIONIC TRIARYL ANALOGS AS ANTI-PROTOZOAN AGENTS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148646-A1 | Dicationic triaryl analogs as anti-protozoan agents | DDT, DDC, DARS1 | RHEB 412/4885F7 3571/4885F2 2666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.