Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 4/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.42 |
| ▸ | HSF1 | Q00613 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 8/20 | 0.37 |
| ▸ | PPARG | P37231 | 6/20 | 0.37 |
| ▸ | PPARD | Q03181 | 5/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6632355 | 0.81 | PTPN1 (0.40) | PTPN2PTPN1ALDH1A1MAPTKMT2A | |
| SCHEMBL6628452 | 0.81 | PTPN1 (0.40) | PTPN2PTPN1ALDH1A1MAPTKMT2A | |
| SCHEMBL6628447 | 0.78 | MAPT (0.42) | PTPN2PTPN1ALDH1A1MAPTKMT2A | |
| SCHEMBL6061710 | 0.78 | MAPT (0.42) | PTPN2PTPN1ALDH1A1MAPTKMT2A | |
| SCHEMBL6048156 | 0.72 | HSF1 (0.39) | HSF1ALDH1A1MAPTKMT2AHSD17B10 | |
| SCHEMBL6630261 | 0.71 | ACACB (0.38) | PTPN2PTPN1 | |
| SCHEMBL10480340 | 0.71 | ALDH1A1 (0.48) | PTPN2PTPN1ALDH1A1LMNATDP1 | |
| SCHEMBL6630253 | 0.69 | ACACB (0.36) | PTPN2PTPN1PPARAPPARGPPARD | |
| SCHEMBL6628528 | 0.68 | CTSK (0.37) | PTPN2PTPN1HSF1ALDH1A1MAPT | |
| SCHEMBL6628517 | 0.68 | CTSK (0.46) | PTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694357-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058348-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-30 | — | — | WO | disclosed |