Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.32 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7042183 | 0.89 | ALDH1A1 (0.37) | ALDH1A1FAAHCES1DAGLAXDH | |
| SCHEMBL6061798 | 0.85 | RAB9A (0.32) | XDHKDM4ERAB9AGLO1CTSS | |
| SCHEMBL6462784 | 0.83 | FAAH (0.37) | FAAHCES1DAGLAXDHKDM4E | |
| SCHEMBL6062899 | 0.77 | FAAH (0.37) | ALDH1A1FAAHCES1DAGLAXDH | |
| SCHEMBL7043387 | 0.76 | XDH (0.31) | XDH | |
| SCHEMBL6464410 | 0.75 | FAAH (0.42) | ALDH1A1FAAHCES1DAGLACTSS | |
| SCHEMBL6468436 | 0.75 | CTSS (0.44) | ALDH1A1XDHCTSS | |
| SCHEMBL6464424 | 0.74 | CTSS (0.43) | ALDH1A1XDHCTSS | |
| SCHEMBL6464404 | 0.73 | DAGLA (0.48) | ALDH1A1FAAHCES1DAGLAXDH | |
| SCHEMBL7044364 | 0.73 | XDH (0.35) | ALDH1A1FAAHCES1DAGLAXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694357-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058348-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-30 | — | — | WO | disclosed |
| EP-1516877-A1 | Amine derivatives as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-23 | — | — | EP | disclosed |