SCHEMBL6063537

SCHEMBL6063537

CS(=O)(=O)C(c1ccccc1)C(NC1CCCCC1)C(=O)NCCCCC(O)c1nc2ccccc2o1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSS P25774 4/20 0.36
TSHR P16473 2/20 0.35
TP53 P04637 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
LMNA P02545 3/20 0.34
SMN1; SMN2 Q16637 3/20 0.34
HTT P42858 2/20 0.34
MAPT P10636 1/20 0.34
ALDH1A1 P00352 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
EPHX1 P07099 1/20 0.34
PTPN2 P17706 1/20 0.34
PTPN1 P18031 1/20 0.34
MET P08581 1/20 0.34
KDR P35968 1/20 0.34
KDM4E B2RXH2 1/20 0.33
FASN P49327 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6063534 0.79 CTSS (0.38) CTSSTSHRLMNASMN1; SMN2HTT
SCHEMBL6206920 0.75 CTSS (0.41) CTSSTSHRTP53CYP1A2CYP3A4
SCHEMBL6063485 0.72 ALDH1A1 (0.35) CTSSLMNASMN1; SMN2HTTMAPT
SCHEMBL6063487 0.72 ALDH1A1 (0.35) CTSSLMNASMN1; SMN2HTTMAPT
SCHEMBL7259493 0.71 CTSS (0.45) CTSS
Hydrochloric Acid SCHEMBL7255797 0.71 CTSS (0.47) CTSSLMNASMN1; SMN2HTTALDH1A1
SCHEMBL6061967 0.71 CTSS (0.46) CTSS
SCHEMBL6633248 0.71 LMNA (0.35) CTSSLMNASMN1; SMN2HTTMAPT
SCHEMBL6629847 0.70 PTPN1 (0.38) ALDH1A1PTPN2PTPN1
SCHEMBL6206025 0.70 MAPT (0.39) CTSSMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1694357-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2006-08-30 EP disclosed
WO-2005058348-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2005-06-30 WO disclosed