Tyrosine

Tyrosine

SCHEMBL606712

NC(Cc1c[nH]cn1)C(=O)O.NC(Cc1ccc(O)cc1)C(=O)O

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 3/20 0.65
PTGS1 P23219 3/20 0.47
ALPI P09923 1/20 0.47
PKM P14618 1/20 0.47
XIAP P98170 1/20 0.47
HSD17B10 Q99714 3/20 0.46
ALOX15 P16050 3/20 0.46
HIF1A Q16665 3/20 0.46
KDM4E B2RXH2 2/20 0.46
ADORA3 P0DMS8 2/20 0.46
HTR2A P28223 2/20 0.46
TDP1 Q9NUW8 2/20 0.46
USP2 O75604 1/20 0.46
EGFR P00533 1/20 0.46
LCK P06239 1/20 0.46
FYN P06241 1/20 0.46
PTGS2 P35354 1/20 0.46
RECQL P46063 1/20 0.46
GRIA2 P42262 1/20 0.44
TPH1 P17752 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tyrosine SCHEMBL8315968 1.00 SLC7A5 (0.65) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL28433898 1.00 SLC7A5 (0.65) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL8316690 1.00 SLC7A5 (0.65) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL606713 1.00 SLC7A5 (0.65) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL25286397 0.96 SLC7A5 (0.60) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL27792454 0.94 SLC7A5 (0.57) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL8904139 0.92 SLC7A5 (0.55) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL28519346 0.92 SLC7A5 (0.55) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL9978769 0.90 SLC7A5 (0.52) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL18297990 0.90 SLC7A5 (0.52) SLC7A5PTGS1ALPIPKMXIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109609476-A α-transaminase and mutant and its application in asymmetric syntheses L-glufosinate-ammonium 浙江工业大学 2019-04-12 CN claimed
CN-108185315-A Sausage without nitrite and preparation method thereof 浙江省农业科学院 2018-06-22 CN claimed
CN-107162855-A A kind of nutrient matrix cultivated for flower plants and nursery stock and preparation method thereof 安徽省百思德农业发展有限公司 2017-09-15 CN claimed
CN-107141134-A A kind of Vegetable Soil modifying agent and preparation method thereof 合肥卓畅农业科技有限公司 2017-09-08 CN claimed
US-9458220-B2 Single-chain insulin agonists exhibiting high activity at the insulin receptor INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2016-10-04 US claimed
US-20150148520-A1 SINGLE-CHAIN INSULIN AGONISTS EXHIBITING HIGH ACTIVITY AT THE INSULIN RECEPTOR UNIV INDIANA RES & TECH CORP (US) 2015-05-28 US claimed
CN-104271595-A Proteins toxic to hemipteran insect species MONSANTO TECHNOLOGY LLC 2015-01-07 CN claimed
US-20130203665-A1 SINGLE-CHAIN INSULIN AGONISTS EXHIBITING HIGH ACTIVITY AT THE INSULIN RECEPTOR INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION 2013-08-08 US claimed
EP-2582719-A2 SINGLE CHAIN INSULIN AGONISTS EXHIBITING HIGH ACTIVITY AT THE INSULIN RECEPTOR Indiana University Research And Technology Corporation (US) 2013-04-24 EP claimed
CN-103068842-A Single chain insulin agonists exhibiting high activity at the insulin receptor UNIV INDIANA RES & TECH CORP 2013-04-24 CN claimed
WO-2011159895-A2 SINGLE CHAIN INSULIN AGONISTS EXHIBITING HIGH ACTIVITY AT THE INSULIN RECEPTOR INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2011-12-22 WO claimed
EP-1390074-A4 NOVEL COMPOSITIONS AND USES THEREFOR UNIV QUEENSLAND (AU) 2007-03-14 EP claimed
EP-1292615-B1 MODIFIED MORBILLIVIRUS V PROTEINS WYETH CORP (US) 2006-10-25 EP claimed
US-20040241177-A1 For producing antigen-primed antigen-presenting cells for eliciting a humoral and cellular immunity against target antigens; intracellular proteolytic degradation of second antigen is increased; immunogens; sustained release UNIQUEST PTY LTD (AU) 2004-12-02 US claimed
EP-1390074-A1 NOVEL COMPOSITIONS AND USES THEREFOR THE UNIVERSITY OF QUEENSLAND (AU) 2004-02-25 EP claimed
US-6664066-B2 Mutant measles virus V protein; gene expression and engineering WYETH HOLDINGS CORPORATION 2003-12-16 US claimed
US-20030206925-A1 MODIFIED MORBILLIVIRUS V PROTEINS WYETH HOLDINGS CORPORATION 2003-11-06 US claimed
WO-2002083181-A1 NOVEL COMPOSITIONS AND USES THEREFOR THE UNIVERSITY OF QUEENSLAND (AU) 2002-10-24 WO claimed
CN-1232504-A 3' genomic promoter region and polymerase gene mutations responsible for attenuation in viruses of order designated mononegavirales AMERICAN CYANAMID CO (US) 1999-10-20 CN claimed
CN-117460418-A Non-dairy creamer composition 皇家戴维艾格伯茨有限公司 2024-01-26 CN disclosed
WO-2023121483-A1 IMMUNOSTIMULATORY COMPOSITIONS VICTORIA LINK LIMITED (NZ) 2023-06-29 WO disclosed
CN-114685681-A Application of HrpNECh protein in pharmacy for recognizing and activating multiple types of receptors and/or membrane proteins and signal pathways thereof 吴伯骥 2022-07-01 CN disclosed
US-11351268-B2 FGF21 C-terminal peptide optimization INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2022-06-07 US disclosed
US-20210198647-A1 Enhancers of Neurolysin Activity TEXAS TECH UNIVERSITY SYSTEM 2021-07-01 US disclosed
US-20200360530-A1 FGF21 C-TERMINAL PEPTIDE OPTIMIZATION UNIV INDIANA RES & TECH CORP (US) 2020-11-19 US disclosed
EP-2970511-B1 INSULIN-INCRETIN CONJUGATES UNIV INDIANA RES & TECH CORP (US) 2020-09-30 EP disclosed
US-10696726-B2 Insulin-incretin conjugates INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2020-06-30 US disclosed
CN-110869384-A Cell factory with improved delivery of iron-sulfur clusters 毒菌公司 2020-03-06 CN disclosed
US-20190336581-A1 IMMUNOSTIMULATORY COMPOSITIONS AND USES THEREFOR THE AUSTRALIAN NATIONAL UNIVERSITY (AU) 2019-11-07 US disclosed
US-20190142963-A1 FGF21 C-TERMINAL PEPTIDE OPTIMIZATION INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION 2019-05-16 US disclosed
CN-109689099-A Composition for preventing or treating IL-8-related diseases 中外制药株式会社 2019-04-26 CN disclosed
EP-3442997-A2 FGF21 C-TERMINAL PEPTIDE OPTIMIZATION Indiana University Research & Technology Corporation (US) 2019-02-20 EP disclosed
US-20180305705-A1 CONSTRUCTS FOR GENE EXPRESSION ANALYSIS GENE STREAM PTY LTD (AU) 2018-10-25 US disclosed
CN-108697906-A By the cancer prevention and the treatment that inhibit soluble tumor necrosis factor 高等教育联邦系统-匹兹堡大学 2018-10-23 CN disclosed
CN-104271595-B Proteins toxic to hemipteran insect species 孟山都技术公司 2018-09-18 CN disclosed
US-20180194827-A1 INSULIN-INCRETIN CONJUGATES UNIV INDIANA RES & TECH CORP (US) 2018-07-12 US disclosed
CN-108271372-A IL-8-BINDING ANTIBODIES AND USES THEREOF 中外制药株式会社 2018-07-10 CN disclosed
US-9993542-B2 Compositions and uses therefor Admedus Vaccines Pty Ltd. (AU) 2018-06-12 US disclosed
US-9994858-B2 Constructs for gene expression analysis GENE STREAM PTY LTD (AU) 2018-06-12 US disclosed
WO-2018018082-A1 IMMUNOSTIMULATORY COMPOSITIONS AND USES THEREFOR THE AUSTRALIAN NATIONAL UNIVERSITY (AU) 2018-02-01 WO disclosed
WO-2017210242-A1 INSULIN-NUCLEAR HORMONE CONJUGATES INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2017-12-07 WO disclosed
US-9795658-B2 Expression system for modulating an immune response ADMEDUS VACCINES PTY LTD (AU) 2017-10-24 US disclosed
WO-2017180988-A2 FGF21 C-TERMINAL PEPTIDE OPTIMIZATION INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2017-10-19 WO disclosed
CN-107162855-A A kind of nutrient matrix cultivated for flower plants and nursery stock and preparation method thereof 安徽省百思德农业发展有限公司 2017-09-15 CN disclosed
CN-107141134-A A kind of Vegetable Soil modifying agent and preparation method thereof 合肥卓畅农业科技有限公司 2017-09-08 CN disclosed
US-20170253932-A1 METHOD FOR DETECTING BCR-ABL INHIBITOR RESISTANCE-RELATED MUTATION AND DATA ACQUISITION METHOD FOR PREDICTING BCR-ABL INHIBITOR RESISTANCE USING THE SAME TOYO KOHAN CO., LTD. (JP) 2017-09-07 US disclosed
US-20170224808-A1 THERAPEUTIC COMPOSITIOJNS AND METHODS FOR INDUCING AN IMMUNE RESPONSE TO HERPES SIMPLEX VIRUS TYPE 2 (HSV-2) ADMEDUS VACCINES PTY LTD (AU) 2017-08-10 US disclosed
EP-3200821-A1 THERAPEUTIC COMPOSITIONS AND METHODS FOR INDUCING AN IMMUNE RESPONSE TO HERPES SIMPLEX VIRUS TYPE 2 (HSV-2) Admedus Vaccines Pty Ltd (AU) 2017-08-09 EP disclosed
US-20170218393-A1 EXPRESSION SYSTEM FOR MODULATING AN IMMUNE RESPONSE ADMEDUS VACCINES PTY LTD (AU) 2017-08-03 US disclosed
EP-1390074-B1 NOVEL COMPOSITIONS AND USES THEREFOR ADMEDUS VACCINES PTY LTD (AU) 2017-06-07 EP disclosed
US-9593340-B2 Expression system for modulating an immune response Admedus Vaccines Pty Ltd. (AU) 2017-03-14 US disclosed
US-9405884-B2 Methods and systems for the analysis of protein samples ABBVIE INC. (US) 2016-08-02 US disclosed
WO-2016049705-A1 THERAPEUTIC COMPOSITIONS AND METHODS FOR INDUCING AN IMMUNE RESPONSE TO HERPES SIMPLEX VIRUS TYPE 2 (HSV-2) ADMEDUS VACCINES PTY LTD (AU) 2016-04-07 WO disclosed
US-20160024169-A1 INSULIN-INCRETIN CONJUGATES INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION 2016-01-28 US disclosed
EP-2970511-A1 INSULIN-INCRETIN CONJUGATES Indiana University Research and Technology Corporation (US) 2016-01-20 EP disclosed
US-20150132325-A1 NOVEL COMPOSITIONS AND USES THEREFOR UNIQUEST PTY LTD (AU) 2015-05-14 US disclosed
CN-104271595-A Proteins toxic to hemipteran insect species MONSANTO TECHNOLOGY LLC 2015-01-07 CN disclosed
US-8858951-B2 Compositions for eliciting an immune response THE UNIVERSITY OF QUEENSLAND (AU) 2014-10-14 US disclosed
WO-2014158900-A1 INSULIN-INCRETIN CONJUGATES INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2014-10-02 WO disclosed
EP-2726097-A2 HERPES VIRUS VACCINE AND METHODS OF USE The Regents Of The University Of California (US) 2014-05-07 EP disclosed
EP-2689250-A1 METHODS AND SYSTEMS FOR THE ANALYSIS OF PROTEIN SAMPLES AbbVie Inc. (US) 2014-01-29 EP disclosed
WO-2013006569-A2 HERPES VIRUS VACCINE AND METHODS OF USE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-01-10 WO disclosed
WO-2012128810-A1 METHODS AND SYSTEMS FOR THE ANALYSIS OF PROTEIN SAMPLES ABBOTT LABORATORIES (US) 2012-09-27 WO disclosed
US-20120245857-A1 Methods and Systems for the Analysis of Protein Samples ABBOTT LABORATORIES (US) 2012-09-27 US disclosed
US-20120177668-A1 IMMUNOMODULATING COMPOSITIONS COMPRISING INTERLEUKIN 13 INHIBITORS AND USES THEREFOR THE AUSTRALIAN NATIONAL UNIVERSITY (AU) 2012-07-12 US disclosed
US-20120040367-A1 CONSTRUCT SYSTEM AND USES THEREFOR THE UNIVERSITY OF QUEENSLAND (AU) 2012-02-16 US disclosed
US-20110287039-A1 EXPRESSION SYSTEM FOR MODULATING AN IMMUNE RESPONSE THE UNIVERSITY OF QUEENSLAND (AU) 2011-11-24 US disclosed
WO-2011009173-A1 CANCER IMMUNOTHERAPY MATER MEDICAL RESEARCH INSTITUTE (AU) 2011-01-27 WO disclosed
US-20110020374-A1 EXPRESSION SYSTEM FOR MODULATING AN IMMUNE RESPONSE THE UNIVERSITY OF QUEENSLAND (AU) 2011-01-27 US disclosed
WO-2011003138-A1 IMMUNOMODULATING COMPOSITIONS COMPRISING INTERLEUKIN 13 INHIBITORS AND USES THEREFOR THE AUSTRALIAN NATIONAL UNIVERSITY (AU) 2011-01-13 WO disclosed
US-20100286229-A1 Modulation of Androgen Receptor for Treatment of Prostate Cancer PANACELA LABS, INC. 2010-11-11 US disclosed
EP-2215269-A1 CONSTRUCT SYSTEM AND USES THEREFOR The University of Queensland (AU) 2010-08-11 EP disclosed
EP-2215231-A1 EXPRESSION SYSTEM FOR MODULATING AN IMMUNE RESPONSE The University of Queensland (AU) 2010-08-11 EP disclosed
CN-101646768-A Attenuated minus-strand RNA viruses DNAVEC CORP JP 2010-02-10 CN disclosed
CN-100558901-C The method of selectively producing male or female sterile plants SYNGENTA LTD (GB) 2009-11-11 CN disclosed
WO-2009049350-A1 EXPRESSION SYSTEM FOR MODULATING AN IMMUNE RESPONSE THE UNIVERSITY OF QUEENSLAND (AU) 2009-04-23 WO disclosed
WO-2009049351-A1 CONSTRUCT SYSTEM AND USES THEREFOR THE UNIVERSITY OF QUEENSLAND (AU) 2009-04-23 WO disclosed
US-20080255000-A1 Method Evolved for Recognition and Testing of Age Related Macular Degeneration (Mert-Armd) THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 2008-10-16 US disclosed
EP-1373528-B1 NOVEL EXPRESSION VECTORS GENE STREAM PTY LTD (AU) 2008-08-13 EP disclosed
EP-1941061-A1 METHOD EVOLVED FOR RECOGNITION AND TESTING OF AGE RELATED MACULAR DEGENERATION (MERT-ARMD) The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services (US) 2008-07-09 EP disclosed
US-20070298417-A1 Constructs for gene expression analysis PROMEGA CORPORATION 2007-12-27 US disclosed
WO-2007056111-A1 METHOD EVOLVED FOR RECOGNITION AND TESTING OF AGE RELATED MACULAR DEGENERATION (MERT-ARMD) THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2007-05-18 WO disclosed
EP-1390074-A4 NOVEL COMPOSITIONS AND USES THEREFOR UNIV QUEENSLAND (AU) 2007-03-14 EP disclosed
US-7157272-B2 Constructs for gene expression analysis GENE STREAM PTY LTD. (AU) 2007-01-02 US disclosed
EP-1292615-B1 MODIFIED MORBILLIVIRUS V PROTEINS WYETH CORP (US) 2006-10-25 EP disclosed
CN-1639344-A Method for selectively producing male or female sterile plants SYNGENTA LTD (GB) 2005-07-13 CN disclosed
EP-1373528-A4 NOVEL EXPRESSION VECTORS GENE STREAM PTY LTD (AU) 2004-12-29 EP disclosed
US-20040241177-A1 For producing antigen-primed antigen-presenting cells for eliciting a humoral and cellular immunity against target antigens; intracellular proteolytic degradation of second antigen is increased; immunogens; sustained release UNIQUEST PTY LTD (AU) 2004-12-02 US disclosed
US-20040209274-A2 Constructs for Gene Expression Analysis GENE STREAM PTY LTD (AU) 2004-10-21 US disclosed
US-20040115704-A1 Constructs for gene expression analysis DALY JOHN (AU) 2004-06-17 US disclosed
EP-1390074-A1 NOVEL COMPOSITIONS AND USES THEREFOR THE UNIVERSITY OF QUEENSLAND (AU) 2004-02-25 EP disclosed
EP-1373528-A1 NOVEL EXPRESSION VECTORS Gene Stream Pty Ltd. (AU) 2004-01-02 EP disclosed
US-6664066-B2 Mutant measles virus V protein; gene expression and engineering WYETH HOLDINGS CORPORATION 2003-12-16 US disclosed
US-20030206925-A1 MODIFIED MORBILLIVIRUS V PROTEINS WYETH HOLDINGS CORPORATION 2003-11-06 US disclosed
WO-2002083181-A1 NOVEL COMPOSITIONS AND USES THEREFOR THE UNIVERSITY OF QUEENSLAND (AU) 2002-10-24 WO disclosed
WO-2002072844-A1 NOVEL EXPRESSION VECTORS GENE STREAM PTY LTD (AU) 2002-09-19 WO disclosed
WO-2002013773-A2 COSMETIC COMPOSITION UNILEVER PLC (GB) 2002-02-21 WO disclosed
CN-1232504-A 3' genomic promoter region and polymerase gene mutations responsible for attenuation in viruses of order designated mononegavirales AMERICAN CYANAMID CO (US) 1999-10-20 CN disclosed
US-5399345-A His at position 52 is substituted with Ser, Arg, or Glu BOEHRINGER MANNHEIM, GMBH (DE) 1995-03-21 US disclosed
US-5399345-A His at position 52 is substituted with Ser, Arg, or Glu BOEHRINGER MANNHEIM, GMBH (DE) 1995-03-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150148520-A1 SINGLE-CHAIN INSULIN AGONISTS EXHIBITING HIGH ACTIVITY AT THE INSULIN RECEPTOR IGF1R, GPR119, IRS1 SLC7A5 454/4885PTGS1 2854/4885ALPI 4406/4885
US-20120177668-A1 IMMUNOMODULATING COMPOSITIONS COMPRISING INTERLEUKIN 13 INHIBITORS AND USES THEREFOR IL15, ICOS, IL2 SLC7A5 3491/4885PTGS1 428/4885ALPI 1425/4885
US-11351268-B2 FGF21 C-terminal peptide optimization FGF23, FGFR1, FGFR3 SLC7A5 2004/4885PTGS1 4814/4885ALPI 2210/4885
US-20160024169-A1 INSULIN-INCRETIN CONJUGATES IAPP, GLP1R, INSR SLC7A5 502/4885PTGS1 4599/4885ALPI 440/4885
US-20190142963-A1 FGF21 C-TERMINAL PEPTIDE OPTIMIZATION FGF23, FGFR1, FGFR3 SLC7A5 2004/4885PTGS1 4814/4885ALPI 2210/4885
US-10696726-B2 Insulin-incretin conjugates GLP1R, IAPP, GIPR SLC7A5 1933/4885PTGS1 4694/4885ALPI 306/4885
US-20130203665-A1 SINGLE-CHAIN INSULIN AGONISTS EXHIBITING HIGH ACTIVITY AT THE INSULIN RECEPTOR IGF1R, GPR119, IRS1 SLC7A5 454/4885PTGS1 2854/4885ALPI 4406/4885
US-20180194827-A1 INSULIN-INCRETIN CONJUGATES GLP1R, IAPP, GIPR SLC7A5 1933/4885PTGS1 4694/4885ALPI 306/4885
US-20210198647-A1 Enhancers of Neurolysin Activity GAP43, NLN, BDNF SLC7A5 1148/4885PTGS1 4683/4885ALPI 4598/4885
US-20200360530-A1 FGF21 C-TERMINAL PEPTIDE OPTIMIZATION FGF23, FGFR1, FGFR3 SLC7A5 2004/4885PTGS1 4814/4885ALPI 2210/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.