Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 7/20 | 0.51 |
| ▸ | DRD3 | P35462 | 4/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 4/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6070007 | 1.00 | MAPT (0.51) | MAPTALDH1A1DRD2DRD3ADRA1A | |
| SCHEMBL6070410 | 0.84 | RECQL (0.54) | MAPTALDH1A1DRD2DRD3ADRA1A | |
| SCHEMBL6070638 | 0.84 | HTR1A (0.52) | MAPTALDH1A1DRD2DRD3ADRA1A | |
| SCHEMBL6070259 | 0.83 | DRD2 (0.51) | MAPTALDH1A1DRD2DRD3ADRA1A | |
| SCHEMBL6070108 | 0.83 | DRD2 (0.51) | MAPTALDH1A1DRD2DRD3ADRA1A | |
| SCHEMBL7793671 | 0.82 | ADRA1D (0.62) | MAPTALDH1A1DRD2DRD3ADRA1A | |
| SCHEMBL6547111 | 0.81 | MAPT (0.53) | MAPTALDH1A1DRD2DRD3ADRA1A | |
| Hydrochloric Acid SCHEMBL7029024 | 0.81 | ADRA1D (0.61) | MAPTALDH1A1DRD2DRD3ADRA1A | |
| Hydrochloric Acid SCHEMBL7029018 | 0.81 | ADRA1D (0.61) | MAPTALDH1A1DRD2DRD3ADRA1A | |
| SCHEMBL6069916 | 0.80 | DRD2 (0.55) | MAPTDRD2DRD3ADRA1ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067518-B2 | Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents | WYETH (US) | 2006-06-27 | — | — | US | claimed |
| US-20050107395-A1 | Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents | WYETH | 2005-05-19 | — | — | US | claimed |
| US-7067518-B2 | Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents | WYETH (US) | 2006-06-27 | — | — | US | disclosed |
| US-20050107395-A1 | Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents | WYETH | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107395-A1 | Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents | HTR1A, HTR5A, HTR2C | MAPT 3040/4885ALDH1A1 1298/4885DRD2 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.