Sugi Predict

Sugi Predict / Compounds / SCHEMBL607022

SCHEMBL607022

SCHEMBL607022

NC(=O)c1ccc(-c2ccccc2F)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 2/20 0.67
▸ L3MBTL1 Q9Y468 2/20 0.67
▸ ALDH1A1 P00352 1/20 0.67
▸ NPC1 O15118 3/20 0.63
▸ RAB9A P51151 3/20 0.63
▸ NPSR1 Q6W5P4 1/20 0.57
▸ MKNK1 Q9BUB5 4/20 0.56
▸ MKNK2 Q9HBH9 3/20 0.56
▸ PARP10 Q53GL7 2/20 0.53
▸ PKM P14618 1/20 0.50
▸ POLB P06746 1/20 0.50
▸ CYP3A4 P08684 1/20 0.50
▸ PARP1 P09874 1/20 0.50
▸ TSHR P16473 1/20 0.50
▸ CYP2C19 P33261 1/20 0.50
▸ RECQL P46063 1/20 0.50
▸ BLM P54132 1/20 0.50
▸ PMP22 Q01453 1/20 0.50
▸ HSD17B10 Q99714 1/20 0.50
▸ TDP1 Q9NUW8 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30958374 1.00 MAPT (0.67) MAPTL3MBTL1ALDH1A1NPC1RAB9A
Hydrochloric Acid SCHEMBL30684981 0.98 MAPT (0.65) MAPTL3MBTL1ALDH1A1NPC1RAB9A
SCHEMBL28264223 0.86 MKNK1 (0.61) MAPTL3MBTL1ALDH1A1NPC1RAB9A
SCHEMBL5583011 0.85 MKNK1 (0.53) MAPTL3MBTL1ALDH1A1NPC1RAB9A
SCHEMBL21246924 0.84 MAPT (0.66) MAPTL3MBTL1ALDH1A1NPC1RAB9A
SCHEMBL412227 0.82 ALDH1A1 (0.64) MAPTL3MBTL1ALDH1A1NPC1RAB9A
SCHEMBL11175255 0.82 ALDH1A1 (0.64) MAPTL3MBTL1ALDH1A1NPC1RAB9A
SCHEMBL9451155 0.81 POLB (0.61) MAPTL3MBTL1ALDH1A1NPC1RAB9A
SCHEMBL5038433 0.81 ALDH1A1 (0.62) MAPTL3MBTL1ALDH1A1NPC1RAB9A
SCHEMBL6191307 0.81 MAPT (0.62) MAPTL3MBTL1ALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110144033-A1 Proteasome Inhibitors and Methods of Using the Same CEPHALON, INC. (US) 2011-06-16 — — US claimed
US-7915236-B2 Proteasome inhibitors and methods of using the same CEPHALON, INC. (US) 2011-03-29 — — US claimed
EP-1660507-B9 PROTEASOME INHIBITORS AND METHODS OF USING THE SAME CEPHALON INC (US) 2010-03-24 — — EP claimed
US-20090291918-A1 PROTEASOME INHIBITORS AND METHODS OF USING THE SAME CEPHALON, INC. (US) 2009-11-26 — — US claimed
EP-1660507-B1 PROTEASOME INHIBITORS AND METHODS OF USING THE SAME CEPHALON INC (US) 2009-08-05 — — EP claimed
CN-1867572-A proteasome inhibitors and methods of use thereof CEPHALON INC (US) 2006-11-22 — — CN claimed
EP-1660507-A2 PROTEASOME INHIBITORS AND METHODS OF USING THE SAME CEPHALON, INC. (US) 2006-05-31 — — EP claimed
US-20050107307-A1 Proteasome inhibitors and methods of using the same TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2005-05-19 — — US claimed
WO-2005021558-A2 PROTEASOME INHIBITORS AND METHODS OF USING THE SAME CEPHALON, INC. (US) 2005-03-10 — — WO claimed
CN-108135887-A Oxazolidinone compounds and its application method as antiseptic 默沙东公司 2018-06-08 — — CN disclosed
EP-1660507-B2 PROTEASOME INHIBITORS AND METHODS OF USING THE SAME MILLENNIUM PHARM INC (US) 2017-01-04 — — EP disclosed
US-9233115-B2 Proteasome inhibitors and methods of using the same MILLENNIUM PHARMACEUTICALS INC. (US) 2016-01-12 — — US disclosed
US-20140088042-A1 Proteasome Inhibitors And Methods Of Using The Same CEPHALON, INC. (US) 2014-03-27 — — US disclosed
US-8546608-B2 Proteasome inhibitors and methods of using the same CEPHALON, INC. (US) 2013-10-01 — — US disclosed
US-20090291918-A1 PROTEASOME INHIBITORS AND METHODS OF USING THE SAME CEPHALON, INC. (US) 2009-11-26 — — US disclosed
US-7576206-B2 Proteasome inhibitors and methods of using the same CEPHALON, INC. (US) 2009-08-18 — — US disclosed
EP-1660507-B1 PROTEASOME INHIBITORS AND METHODS OF USING THE SAME CEPHALON INC (US) 2009-08-05 — — EP disclosed
US-20060287378-A1 Novel pyrroles and imidazoles WARNER-LAMBERT COMPANY LLC 2006-12-21 — — US disclosed
US-20050239857-A1 Novel imidazoles BOLTON GARY L 2005-10-27 — — US disclosed
US-20050107307-A1 Proteasome inhibitors and methods of using the same TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2005-05-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090291918-A1 PROTEASOME INHIBITORS AND METHODS OF USING THE SAME PSMB11, PSMB5, PSMB6 MAPT 2121/4885L3MBTL1 479/4885ALDH1A1 3935/4885
US-20050107307-A1 Proteasome inhibitors and methods of using the same PSMB11, PSMB5, PSMB6 MAPT 2121/4885L3MBTL1 479/4885ALDH1A1 3935/4885
US-20060287378-A1 Novel pyrroles and imidazoles PPIP5K2, PPIE, PPOX MAPT 229/4885L3MBTL1 4821/4885ALDH1A1 2496/4885
US-20050239857-A1 Novel imidazoles HMGCR, HMGB2, HMGB3 MAPT 1367/4885L3MBTL1 4624/4885ALDH1A1 560/4885
US-20140088042-A1 Proteasome Inhibitors And Methods Of Using The Same PSMB11, PSMB5, PSMB6 MAPT 2121/4885L3MBTL1 479/4885ALDH1A1 3935/4885
US-20110144033-A1 Proteasome Inhibitors and Methods of Using the Same PSMB11, PSMB5, PSMB6 MAPT 2121/4885L3MBTL1 479/4885ALDH1A1 3935/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.