Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 12/20 | 0.43 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.41 |
| ▸ | LGMN | Q99538 | 1/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.36 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6074839 | 0.81 | ADAMTS5 (0.47) | ADAMTS5ADAMTS4L3MBTL3L3MBTL1ADAM17 | |
| SCHEMBL6074498 | 0.77 | MAPT (0.51) | LGMNALDH1A1MAPTHRH3 | |
| SCHEMBL6680323 | 0.71 | LGMN (0.54) | LGMNL3MBTL3L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL6074426 | 0.71 | LGMN (0.50) | LGMNL3MBTL3L3MBTL1ALDH1A1MAPT | |
| SCHEMBL23387256 | 0.70 | ITGB3 (0.56) | LGMNL3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL5546662 | 0.69 | POLB (0.55) | LGMNALDH1A1GAAKDM4EMAPT | |
| SCHEMBL6704329 | 0.69 | PPARG (0.44) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL4938700 | 0.68 | HRH3 (0.56) | LGMNL3MBTL3L3MBTL1ALDH1A1MAPT | |
| SCHEMBL6073828 | 0.68 | LGMN (0.47) | LGMNL3MBTL3L3MBTL1ALDH1A1GAA | |
| SCHEMBL6132758 | 0.68 | LGMN (0.52) | LGMNALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7022716-B2 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | WYETH (US) | 2006-04-04 | — | — | US | disclosed |
| US-20030144326-A1 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | WYETH | 2003-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144326-A1 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | ADRB1, ADRB3, ADRB2 | ADAMTS5 3757/4885ADAMTS4 4268/4885LGMN 4736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.