Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ACP3 | P15309 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6075831 | 0.85 | PIN1 (0.38) | PIN1ALDH1A1MMP8RECQLPOLB | |
| SCHEMBL16795787 | 0.73 | PIN1 (0.41) | PIN1ALDH1A1MMP8RECQLPOLB | |
| SCHEMBL27816341 | 0.73 | MMP8 (0.51) | PIN1ALDH1A1MMP8POLBMEN1 | |
| SCHEMBL363983 | 0.71 | TSHR (0.48) | PIN1ALDH1A1MMP8MEN1KMT2A | |
| SCHEMBL7509738 | 0.71 | MMP8 (0.51) | PIN1ALDH1A1MMP8POLBMEN1 | |
| SCHEMBL8111908 | 0.70 | CASP1 (0.48) | PIN1ALDH1A1MMP8RECQLACP3 | |
| SCHEMBL27512117 | 0.70 | PPARA (0.41) | PIN1POLBACP3MEN1KMT2A | |
| SCHEMBL27774182 | 0.70 | MMP8 (0.44) | PIN1ALDH1A1MMP8RECQLPOLB | |
| SCHEMBL1190661 | 0.69 | CASP1 (0.49) | PIN1MMP8POLBMEN1KMT2A | |
| SCHEMBL9127785 | 0.68 | TDP1 (0.45) | PIN1ALDH1A1MMP8POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115633-B2 | Central nervous system disorders; Alzheimer's diseases; eating disorders | GLAXOSMITHKLINE S.P.A. (IT) | 2006-10-03 | — | — | US | disclosed |
| US-20040029917-A1 | Benzosuberonylpiperdine compounds as analgesics | GLAXOSMITHKLINE S.P.A. (IT) | 2004-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040029917-A1 | Benzosuberonylpiperdine compounds as analgesics | OPRK1, OPRL1, OPRM1 | PIN1 4655/4885ALDH1A1 99/4885MMP8 3000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.