Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.75 |
| ▸ | SPR | P35270 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | IDO1 | P14902 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.64 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.64 |
| ▸ | ACHE | P22303 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL735830 | 0.88 | KMT2A (0.72) | KDM4EALDH1A1CYP1A2CYP3A4MAPT | |
| SCHEMBL25076892 | 0.84 | HTR2A (0.68) | TRPV1SPRKDM4EALDH1A1NPSR1 | |
| SCHEMBL7023934 | 0.83 | LMNA (0.64) | TRPV1SPRKDM4EALDH1A1NPSR1 | |
| SCHEMBL8802846 | 0.83 | TRPM8 (0.68) | TRPV1SPRKDM4EALDH1A1NPSR1 | |
| SCHEMBL1960963 | 0.82 | SPR (0.78) | TRPV1SPRKDM4EALDH1A1NPSR1 | |
| SCHEMBL807557 | 0.82 | TRPV1 (0.70) | TRPV1SPRKDM4EALDH1A1NPSR1 | |
| SCHEMBL31277254 | 0.82 | ACHE (0.75) | TRPV1SPRKDM4EALDH1A1NPSR1 | |
| SCHEMBL5342883 | 0.82 | ACHE (0.75) | TRPV1SPRKDM4EALDH1A1NPSR1 | |
| SCHEMBL6075817 | 0.82 | TRPV1 (0.61) | TRPV1KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7100086 | 0.82 | SPR (0.76) | TRPV1SPRKDM4EALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7126012-B2 | Substituted cyclic compounds | LES LABORATOIRES SERVIER (FR) | 2006-10-24 | — | — | US | disclosed |
| US-7115752-B2 | Substituted cyclic compounds | LES LABORATOIRES SERVIER (FR) | 2006-10-03 | — | — | US | disclosed |
| US-20050124682-A1 | Substituted cyclic compounds | LESIEUR DANIEL (FR) | 2005-06-09 | — | — | US | disclosed |
| US-6872851-B1 | Substituted cyclic compounds, preparation method and pharmaceutical compositions containing them | LES LABORATORIES SERVIER (FR) | 2005-03-29 | — | — | US | disclosed |
| US-20050059729-A1 | Substituted cyclic compounds | LESIEUR DANIEL (FR) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059729-A1 | Substituted cyclic compounds | CCNY, CCNT2, TECR | TRPV1 2763/4885SPR 843/4885KDM4E 1740/4885 |
| US-20050124682-A1 | Substituted cyclic compounds | CCNY, CCNT2, TECR | TRPV1 2763/4885SPR 843/4885KDM4E 1740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.