Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 6/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.51 |
| ▸ | CDK4 | P11802 | 9/20 | 0.51 |
| ▸ | CCND1 | P24385 | 9/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.51 |
| ▸ | CDK2 | P24941 | 4/20 | 0.51 |
| ▸ | NQO1 | P15559 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.47 |
| ▸ | PRKCG | P05129 | 2/20 | 0.47 |
| ▸ | PRKCB | P05771 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5438544 | 0.85 | PRKCA (0.71) | PRKCAROCK2CDK4CCND1CCNE2 | |
| SCHEMBL14708732 | 0.80 | ROCK2 (0.58) | PRKCAROCK2CDK4CCND1CCNE2 | |
| SCHEMBL8122606 | 0.75 | CDK4 (0.77) | PRKCAROCK2CDK4CCND1CCNE2 | |
| SCHEMBL5440800 | 0.75 | CDK4 (0.70) | PRKCAROCK2CDK4CCND1CCNE2 | |
| SCHEMBL16504230 | 0.74 | CDK4 (0.60) | PRKCAROCK2CDK4CCND1NQO1 | |
| SCHEMBL14498911 | 0.74 | ROCK2 (0.55) | PRKCAROCK2CDK4CCND1CCNE2 | |
| SCHEMBL8317372 | 0.73 | PRKCA (1.00) | PRKCAROCK2CDK4CCND1CCNE2 | |
| SCHEMBL17682020 | 0.72 | NQO1 (0.53) | PRKCAROCK2CDK4CCND1CCNE2 | |
| SCHEMBL6080838 | 0.70 | ROCK2 (0.48) | PRKCAROCK2CDK4CCND1CCNE2 | |
| SCHEMBL5828670 | 0.70 | PARP1 (0.59) | PRKCAROCK2CDK4CCND1CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060004428-A1 | Pyrrolo (3,4-c) carbazole and pyrido (2,3-b) pyrrolo (3,4-e) indole derivatives, preparation method and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2006-01-05 | — | — | US | disclosed |