Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.52 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.52 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.49 |
| ▸ | LTA4H | P09960 | 6/20 | 0.49 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6081977 | 0.86 | LTA4H (0.56) | MCHR1KCNH2LTA4HMCHR2HRH3 | |
| SCHEMBL6207626 | 0.84 | GRIN2D (0.65) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| SCHEMBL6081563 | 0.83 | LTA4H (0.55) | MCHR1KCNH2LTA4HMCHR2HRH3 | |
| Hydrochloric Acid SCHEMBL6208483 | 0.82 | GRIN2D (0.64) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| SCHEMBL1728741 | 0.82 | LTA4H (0.51) | MCHR1KCNH2LTA4HMCHR2HRH3 | |
| SCHEMBL1728503 | 0.80 | LTA4H (0.54) | MCHR1KCNH2LTA4HMCHR2HRH3 | |
| SCHEMBL1728438 | 0.80 | LTA4H (0.56) | MCHR1KCNH2LTA4HMCHR2HRH3 | |
| SCHEMBL6083117 | 0.80 | DRD2 (0.59) | MCHR1KCNH2LTA4HMCHR2HRH3 | |
| SCHEMBL1728674 | 0.80 | ALDH1A1 (0.60) | MCHR1KCNH2LTA4HMCHR2HRH3 | |
| SCHEMBL6081709 | 0.80 | TMEM97 (0.69) | MCHR1KCNH2LTA4HHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |