SCHEMBL609006

SCHEMBL609006

CCC(=O)NC(c1ccc(OC)cc1)c1cc(Cl)c2cccnc2c1O

nearest known ligand 0.84

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ADAMTS5 Q9UNA0 9/20 0.84
KDM4E B2RXH2 6/20 0.80
ALOX12 P18054 5/20 0.80
NPC1 O15118 4/20 0.80
RAB9A P51151 4/20 0.80
KMT2A Q03164 3/20 0.80
L3MBTL1 Q9Y468 1/20 0.80
MEN1 O00255 2/20 0.80
HTT P42858 1/20 0.80
LMNA P02545 4/20 0.74
TP53 P04637 2/20 0.74
SMN1; SMN2 Q16637 2/20 0.70
TDP1 Q9NUW8 2/20 0.70
MITF O75030 1/20 0.70
HSP90AA1 P07900 1/20 0.70
POLB P06746 1/20 0.68
MCL1 Q07820 1/20 0.67
THRB P10828 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30876659 0.93 ADAMTS5 (0.83) ADAMTS5KDM4EALOX12NPC1RAB9A
SCHEMBL24634657 0.93 ADAMTS5 (0.83) ADAMTS5KDM4EALOX12NPC1RAB9A
SCHEMBL27196486 0.92 ADAMTS5 (0.84) ADAMTS5KDM4EALOX12NPC1RAB9A
SCHEMBL31533569 0.91 ADAMTS5 (0.85) ADAMTS5KDM4EALOX12NPC1RAB9A
SCHEMBL31672845 0.91 ADAMTS5 (0.79) ADAMTS5KDM4EALOX12NPC1RAB9A
SCHEMBL2153202 0.91 ADAMTS5 (0.79) ADAMTS5KDM4EALOX12NPC1RAB9A
SCHEMBL27790131 0.91 KDM4E (0.78) ADAMTS5KDM4EALOX12NPC1RAB9A
SCHEMBL23792596 0.90 ALOX12 (0.86) ADAMTS5KDM4EALOX12NPC1RAB9A
SCHEMBL2153066 0.90 ALOX12 (0.86) ADAMTS5KDM4EALOX12NPC1RAB9A
SCHEMBL2598275 0.89 KDM4E (1.00) ADAMTS5KDM4EALOX12NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210198244-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2021-07-01 US claimed
US-20170334890-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2017-11-23 US claimed
US-20150210674-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2015-07-30 US claimed
WO-2010068767-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2010-06-17 WO claimed
US-20210198244-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2021-07-01 US disclosed
US-10745390-B2 Small molecule activators of mitochondrial function THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2020-08-18 US disclosed
US-20170334890-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2017-11-23 US disclosed
US-9695157-B2 Small molecule activators of mitochondrial function THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2017-07-04 US disclosed
US-20150210674-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2015-07-30 US disclosed
US-9000009-B2 Small molecule activators of mitochondrial function THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2015-04-07 US disclosed
US-20120041023-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2012-02-16 US disclosed
WO-2010068767-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2010-06-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150210674-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION TFAM, TFB2M, GFM1 ADAMTS5 4672/4885KDM4E 4095/4885ALOX12 678/4885
US-20170334890-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION TFAM, TFB2M, GFM1 ADAMTS5 4672/4885KDM4E 4095/4885ALOX12 678/4885
US-20120041023-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION TFAM, TFB2M, GFM1 ADAMTS5 4693/4885KDM4E 4129/4885ALOX12 768/4885
US-10745390-B2 Small molecule activators of mitochondrial function TFAM, TFB2M, GFM1 ADAMTS5 4672/4885KDM4E 4095/4885ALOX12 678/4885
US-20210198244-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION TFAM, TFB2M, GFM1 ADAMTS5 4672/4885KDM4E 4095/4885ALOX12 678/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.