Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 4/20 | 0.39 |
| ▸ | TXK | P42681 | 4/20 | 0.39 |
| ▸ | SYK | P43405 | 4/20 | 0.39 |
| ▸ | ITK | Q08881 | 4/20 | 0.39 |
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 3/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1023455 | 0.83 | NPC1 (0.38) | — | |
| SCHEMBL762335 | 0.79 | KIF11 (0.41) | LCKSYKITK | |
| SCHEMBL18687266 | 0.78 | CNR2 (0.35) | ESR1ARESR2 | |
| SCHEMBL23069661 | 0.77 | CYP3A4 (0.30) | — | |
| SCHEMBL1073023 | 0.75 | SHBG (0.41) | ESR1AR | |
| SCHEMBL5720456 | 0.75 | TSHR (0.38) | — | |
| SCHEMBL203467 | 0.75 | METAP2 (0.44) | — | |
| SCHEMBL31189943 | 0.74 | ESR1 (0.50) | ESR1ARESR2 | |
| SCHEMBL6090248 | 0.73 | MAPT (0.38) | LCKTXKSYKITKPIKFYVE | |
| SCHEMBL29370571 | 0.73 | SCN10A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235222-A1 | Indole-derivative modulators of steroid hormone nuclear receptors | ELI LILLY AND COMPANY (US) | 2006-10-19 | — | — | US | disclosed |
| EP-1597254-A1 | INDOLE-DERIVATIVE MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | Eli Lilly and Company (US) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004067529-A1 | INDOLE-DERIVATIVE MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | ELI LILLY AND COMPANY (US) | 2004-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235222-A1 | Indole-derivative modulators of steroid hormone nuclear receptors | NR3C2, NR5A1, MC2R | LCK 1360/4885TXK 3029/4885SYK 2839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.