Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | TNF | P01375 | 1/20 | 0.48 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.48 |
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | CCR8 | P51685 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RIOK2 | Q9BVS4 | 4/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | NOS3 | P29474 | 3/20 | 0.44 |
| ▸ | NOS1 | P29475 | 3/20 | 0.44 |
| ▸ | NOS2 | P35228 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.44 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29404716 | 0.85 | CCR1 (0.48) | CCR1CCR5CCR8RIOK2GSK3A | |
| SCHEMBL17310152 | 0.83 | FERMT2 (0.57) | CCR1CCR5CCR8RIOK2GSK3A | |
| SCHEMBL7832301 | 0.82 | HRH3 (0.51) | CCR1CCR5CCR8RIOK2GSK3A | |
| SCHEMBL2177165 | 0.81 | ALDH1A1 (0.52) | ROCK2ROCK1ALDH1A1SMN1; SMN2MAPK10 | |
| SCHEMBL828151 | 0.77 | KARS1 (0.63) | KDM4DALDH1A1SMN1; SMN2NOS2KARS1 | |
| SCHEMBL11465581 | 0.77 | HSP90AA1 (0.54) | ROCK2ROCK1CCR1CCR5CCR8 | |
| SCHEMBL17700550 | 0.77 | HRH4 (0.50) | ROCK2ROCK1CCR1CCR5CCR8 | |
| SCHEMBL30356806 | 0.75 | RIOK2 (0.50) | ROCK2ROCK1KDM4DALDH1A1SMN1; SMN2 | |
| SCHEMBL17310202 | 0.75 | DYRK1A (0.49) | RIOK2GSK3AMAPK10L3MBTL1 | |
| SCHEMBL25715010 | 0.75 | NOS2 (0.46) | ROCK2ROCK1TNFKDM4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060270714-A1 | Novel n-substituted 2-aminopyridine derivatives | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270714-A1 | Novel n-substituted 2-aminopyridine derivatives | NOS1, NOS2, NOS3 | ROCK2 1853/4885ROCK1 1441/4885TNF 699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.