Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 9/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6094051 | 0.83 | MAPT (0.45) | RAB9ASMN1; SMN2ALDH1A1KDM4EHCRTR1 | |
| SCHEMBL6092305 | 0.83 | AR (0.42) | KDM4EMAPT | |
| SCHEMBL6091074 | 0.76 | AR (0.38) | KDM4ETDP1MAPTTHRB | |
| SCHEMBL6095259 | 0.74 | TNFRSF1A (0.50) | ALDH1A1KDM4E | |
| SCHEMBL8578012 | 0.73 | LTA4H (0.45) | RAB9ASMN1; SMN2ALDH1A1KDM4EHCRTR1 | |
| SCHEMBL27204316 | 0.73 | BAZ2B (0.53) | ALDH1A1KDM4EHCRTR1HCRTR2MAPT | |
| SCHEMBL6090977 | 0.72 | ALDH1A1 (0.41) | RAB9ASMN1; SMN2ALDH1A1KDM4EMYC | |
| SCHEMBL6092497 | 0.72 | KMT2A (0.49) | ALDH1A1KDM4EMAPK1TDP1MAPT | |
| Bicarbonate SCHEMBL7346713 | 0.71 | HPGD (0.51) | RAB9ASMN1; SMN2ALDH1A1KDM4ECTNNB1 | |
| SCHEMBL932848 | 0.71 | ALOX15 (0.53) | RAB9ASMN1; SMN2ALDH1A1KDM4EMYC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060063828-A1 | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof | ATHEROGENICS, INC. | 2006-03-23 | — | — | US | claimed |
| US-20060063828-A1 | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof | ATHEROGENICS, INC. | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063828-A1 | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof | ABCB11, CEL, CYP46A1 | RAB9A 2477/4885SMN1; SMN2 2250/4885ALDH1A1 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.