Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6772013 | 0.78 | LMNA (0.50) | GAAMAPK1MAPTTP53KDM4E | |
| SCHEMBL6094152 | 0.69 | ROCK2 (0.35) | DGAT1MAPTTP53PIK3CAMTOR | |
| SCHEMBL7368988 | 0.67 | MAPT (0.48) | GAAMAPK1MAPTTP53KDM4E | |
| SCHEMBL6093288 | 0.61 | ROCK2 (0.39) | MAPK1MAPTTP53ALDH1A1KMT2A | |
| SCHEMBL15962633 | 0.61 | PIK3CA (0.55) | TRPV1DGAT1PIK3CAMTORRAB9A | |
| SCHEMBL6093985 | 0.61 | ROCK2 (0.35) | MAPTKMT2ANPSR1RAB9A | |
| SCHEMBL6092075 | 0.60 | HCAR3 (0.40) | MAPK1MAPTTP53ALDH1A1KMT2A | |
| SCHEMBL30010142 | 0.60 | TRPV1 (0.55) | TRPV1DGAT1PIK3CAMTORRAB9A | |
| SCHEMBL6092785 | 0.60 | KIT (0.41) | MAPTKDM4EALDH1A1KMT2AKIT | |
| SCHEMBL6394774 | 0.59 | ROCK2 (0.42) | MAPTTP53ALDH1A1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109351-B1 | Fused pyrrolecarboxamides; GABA brain receptor ligands | NEUROGEN CORPORATION (US) | 2006-09-19 | — | — | US | disclosed |
| US-20050014939-A1 | Fused pyrrolecarboxamides: GABA brain receptor ligands | NEUROGEN CORPORATION | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014939-A1 | Fused pyrrolecarboxamides: GABA brain receptor ligands | GABRB2, GABRB1, GABRB3 | TRPV1 780/4885DGAT1 4386/4885FGFR3 3570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.