Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 6/20 | 0.42 |
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | MMP3 | P08254 | 3/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | MMP13 | P45452 | 4/20 | 0.42 |
| ▸ | MMP7 | P09237 | 3/20 | 0.42 |
| ▸ | MMP12 | P39900 | 3/20 | 0.42 |
| ▸ | ACE | P12821 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27853852 | 0.79 | ALDH1A1 (0.44) | LMNAKCNA5ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL28773565 | 0.77 | MMP1 (0.47) | LMNAKCNA5ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL17323164 | 0.74 | PSIP1 (0.48) | LMNATSHRHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL6094393 | 0.73 | TSHR (0.41) | LMNATSHRHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL6094391 | 0.73 | TSHR (0.41) | LMNATSHRHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL6097607 | 0.73 | TSHR (0.41) | LMNATSHRHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL9703092 | 0.73 | CA12 (0.46) | LMNAALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1735426 | 0.72 | SMN1; SMN2 (0.46) | LMNATSHRHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL4968247 | 0.72 | MMP1 (0.64) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL6097619 | 0.71 | CA12 (0.51) | LMNATSHRHSD17B10ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101892-B2 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. | 2006-09-05 | — | — | US | disclosed |
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | HTR7, HTR2C, HTR1A | LMNA 3190/4885TSHR 88/4885HSD17B10 2214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.