Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL6101423 | 0.99 | S100A4 (0.46) | S100A4MEN1KMT2AGRIN2DGRIN3B | |
| Water SCHEMBL8467556 | 0.89 | MEN1 (0.38) | S100A4MEN1KMT2AGRIN2DGRIN3B | |
| SCHEMBL6106397 | 0.83 | ALDH1A1 (0.51) | S100A4MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL6099876 | 0.83 | LMNA (0.40) | S100A4MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL6100932 | 0.82 | S100A4 (0.34) | S100A4MEN1KMT2AGRIN2DGRIN3B | |
| SCHEMBL6100934 | 0.82 | S100A4 (0.34) | S100A4MEN1KMT2AGRIN2DGRIN3B | |
| SCHEMBL3354370 | 0.81 | S100A4 (0.42) | S100A4MEN1KMT2AGRIN2DGRIN3B | |
| SCHEMBL842306 | 0.81 | MAPT (0.42) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6100506 | 0.80 | MAPT (0.47) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6099481 | 0.78 | ALDH1A1 (0.40) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912565-B1 | PROCESS FOR PREPARING IMIDAZOQUINOLINAMINES | MINNESOTA MINING & MFG (US) | 2004-04-14 | — | — | EP | claimed |
| US-20040019213-A1 | Process for preparing imidazoquinolinamines | 3M INNOVATIVE PROPERTIES COMPANY | 2004-01-29 | — | — | US | claimed |
| US-6613902-B2 | Induce biosynthesis of cytokines such as interferons, interleukins, and tumor necrosis factor in humans and in mice. | 3M INNOVATIVE PROPERTIES COMPANY | 2003-09-02 | — | — | US | claimed |
| US-20030153762-A1 | Process for preparing imidazoquinolinamines | 3M INNOVATIVE PROPERTIES COMPANY | 2003-08-14 | — | — | US | claimed |
| US-20030130516-A1 | PROCESS FOR PREPARING IMIDAZOQUINOLINAMINES | 3M INNOVATIVE PROPERTIES COMPANY | 2003-07-10 | — | — | US | claimed |
| US-20020188127-A1 | Process for preparing imidazoquinolinamines | 3M INNOVATIVE PROPERTIES COMPANY | 2002-12-12 | — | — | US | claimed |
| EP-0912565-A1 | PROCESS FOR PREPARING IMIDAZOQUINOLINAMINES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1999-05-06 | — | — | EP | claimed |
| US-5741908-A | Process for reparing imidazoquinolinamines | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1998-04-21 | — | — | US | claimed |
| WO-1997048704-A1 | PROCESS FOR PREPARING IMIDAZOQUINOLINAMINES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-12-24 | — | — | WO | claimed |
| US-20080161573-A1 | PROCESS FOR THE PREPARATION OF IMIQUIMOD AND INTERMEDIATES THEREOF | DIPHARMA S.P.A. (IT) | 2008-07-03 | — | — | US | disclosed |
| US-7301027-B2 | Process for the preparation of Imiquimod and intermediates thereof | DIPHARMA S.P.A. (IT) | 2007-11-27 | — | — | US | disclosed |
| US-7301027-B2 | Process for the preparation of Imiquimod and intermediates thereof | DIPHARMA S.P.A. (IT) | 2007-11-27 | — | — | US | disclosed |
| US-7026482-B2 | Process for preparing imidazoquinolinamines | MEDICIS PHARMACEUTICAL CORPORATION | 2006-04-11 | — | — | US | disclosed |
| US-6989389-B2 | Aryl ether substituted imidazoquinolines | 3M INNOVATIVE PROPERTIES CO. (US) | 2006-01-24 | — | — | US | disclosed |
| EP-0912565-A1 | PROCESS FOR PREPARING IMIDAZOQUINOLINAMINES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1999-05-06 | — | — | EP | disclosed |
| EP-0912564-A1 | PROCESS FOR PREPARING TETRAHYDROIMIDAZOQUINOLINAMINES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1999-05-06 | — | — | EP | disclosed |
| US-5741908-A | Process for reparing imidazoquinolinamines | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1998-04-21 | — | — | US | disclosed |
| WO-1997048704-A1 | PROCESS FOR PREPARING IMIDAZOQUINOLINAMINES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-12-24 | — | — | WO | disclosed |
| WO-1997048703-A1 | PROCESS FOR PREPARING TETRAHYDROIMIDAZOQUINOLINAMINES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-12-24 | — | — | WO | disclosed |
| US-5693811-A | Process for preparing tetrahdroimidazoquinolinamines | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161573-A1 | PROCESS FOR THE PREPARATION OF IMIQUIMOD AND INTERMEDIATES THEREOF | MYD88, TLR7, MAVS | S100A4 2595/4885MEN1 3676/4885KMT2A 1184/4885 |
| US-20040019213-A1 | Process for preparing imidazoquinolinamines | VAT1, QARS1, TALDO1 | S100A4 2670/4885MEN1 1398/4885KMT2A 542/4885 |
| US-20020188127-A1 | Process for preparing imidazoquinolinamines | VAT1, QARS1, TALDO1 | S100A4 2670/4885MEN1 1398/4885KMT2A 542/4885 |
| US-20030130516-A1 | PROCESS FOR PREPARING IMIDAZOQUINOLINAMINES | VAT1, QARS1, TALDO1 | S100A4 2670/4885MEN1 1398/4885KMT2A 542/4885 |
| US-20030153762-A1 | Process for preparing imidazoquinolinamines | VAT1, QARS1, TALDO1 | S100A4 2670/4885MEN1 1398/4885KMT2A 542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.