Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 4/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | S100A4 | P26447 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6106397 | 0.83 | ALDH1A1 (0.51) | LMNAALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL6097459 | 0.83 | S100A4 (0.47) | LMNAALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL3358573 | 0.83 | HASPIN (0.39) | LMNAALDH1A1MAPTPOLBHTT | |
| Water SCHEMBL6101423 | 0.82 | S100A4 (0.46) | LMNAALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL842477 | 0.81 | NPY1R (0.36) | LMNAALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL3355530 | 0.81 | NPY1R (0.36) | LMNAALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL6100932 | 0.79 | S100A4 (0.34) | LMNAALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL6100934 | 0.79 | S100A4 (0.34) | LMNAALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL6106735 | 0.79 | KDM4E (0.43) | LMNAALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL6100506 | 0.77 | MAPT (0.47) | LMNAALDH1A1KDM4ESMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7026482-B2 | Process for preparing imidazoquinolinamines | MEDICIS PHARMACEUTICAL CORPORATION | 2006-04-11 | — | — | US | disclosed |
| US-6989389-B2 | Aryl ether substituted imidazoquinolines | 3M INNOVATIVE PROPERTIES CO. (US) | 2006-01-24 | — | — | US | disclosed |
| US-6953804-B2 | Aryl ether substituted imidazoquinolines | 3M INNOVATIVE PROPERTIES CO. (US) | 2005-10-11 | — | — | US | disclosed |
| US-6897314-B2 | Process for preparing imidazoquinolinamines | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2005-05-24 | — | — | US | disclosed |
| US-20050096470-A1 | Process for preparing imidazoquinolinamines | 3M INNOVATIVE PROPERTIES COMPANY | 2005-05-05 | — | — | US | disclosed |
| US-20040138248-A1 | Aryl ether substituted imidazoquinolines | 3M INNOVATIVE PROPERTIES COMPANY | 2004-07-15 | — | — | US | disclosed |
| US-20040106640-A1 | Aryl ether substituted imidazoquinolines | COLEY PHARMACEUTICAL GROUP, INC. | 2004-06-03 | — | — | US | disclosed |
| US-20040072858-A1 | Heterocyclic ether substituted imidazoquinolines | 3M INNOVATIVE PROPERTIES COMPANY | 2004-04-15 | — | — | US | disclosed |
| EP-0912565-B1 | PROCESS FOR PREPARING IMIDAZOQUINOLINAMINES | MINNESOTA MINING & MFG (US) | 2004-04-14 | — | — | EP | disclosed |
| US-20040019213-A1 | Process for preparing imidazoquinolinamines | 3M INNOVATIVE PROPERTIES COMPANY | 2004-01-29 | — | — | US | disclosed |
| WO-2002046193-A2 | HETEROCYCLIC ETHER SUBSTITUTED IMIDAZOQUINOLINES | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2002-06-13 | — | — | WO | disclosed |
| WO-2002046189-A2 | ARYL ETHER SUBSTITUTED IMIDAZOQUINOLINES | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2002-06-13 | — | — | WO | disclosed |
| US-6150523-A | Process for preparing imidazoquinolinamines | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2000-11-21 | — | — | US | disclosed |
| US-5998619-A | Process for preparing imidazoquinolinamines | 3M INNOVATIVE PROPERTIES COMPANY (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0912565-A1 | PROCESS FOR PREPARING IMIDAZOQUINOLINAMINES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1999-05-06 | — | — | EP | disclosed |
| EP-0912564-A1 | PROCESS FOR PREPARING TETRAHYDROIMIDAZOQUINOLINAMINES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1999-05-06 | — | — | EP | disclosed |
| US-5741908-A | Process for reparing imidazoquinolinamines | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1998-04-21 | — | — | US | disclosed |
| WO-1997048703-A1 | PROCESS FOR PREPARING TETRAHYDROIMIDAZOQUINOLINAMINES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-12-24 | — | — | WO | disclosed |
| WO-1997048704-A1 | PROCESS FOR PREPARING IMIDAZOQUINOLINAMINES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-12-24 | — | — | WO | disclosed |
| US-5693811-A | Process for preparing tetrahdroimidazoquinolinamines | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138248-A1 | Aryl ether substituted imidazoquinolines | IRF3, IFNG, MYD88 | LMNA 3956/4885ALDH1A1 1364/4885KDM4E 419/4885 |
| US-20040106640-A1 | Aryl ether substituted imidazoquinolines | IRF3, IFNG, MYD88 | LMNA 3956/4885ALDH1A1 1364/4885KDM4E 419/4885 |
| US-20040019213-A1 | Process for preparing imidazoquinolinamines | VAT1, QARS1, TALDO1 | LMNA 1618/4885ALDH1A1 1648/4885KDM4E 692/4885 |
| US-20050096470-A1 | Process for preparing imidazoquinolinamines | ITPA, INMT, PIP4K2C | LMNA 1093/4885ALDH1A1 1777/4885KDM4E 983/4885 |
| US-20040072858-A1 | Heterocyclic ether substituted imidazoquinolines | IFNG, IL2, IRF3 | LMNA 3958/4885ALDH1A1 2486/4885KDM4E 752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.