Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6291686 | 0.78 | NPC1 (0.53) | NPC1RAB9AMAPTALDH1A1MAPK10 | |
| SCHEMBL1789932 | 0.75 | NPC1 (0.46) | NPC1RAB9AMAPTALDH1A1MAPK10 | |
| SCHEMBL30421864 | 0.74 | MAPT (0.49) | NPC1RAB9AMAPTALDH1A1MAPK10 | |
| SCHEMBL713066 | 0.73 | NPC1 (0.47) | NPC1RAB9AMAPTALDH1A1MAPK10 | |
| SCHEMBL29942654 | 0.72 | NPC1 (0.63) | NPC1RAB9AMAPTALDH1A1MAPK10 | |
| SCHEMBL29966674 | 0.72 | NPC1 (0.63) | NPC1RAB9AMAPTALDH1A1MAPK10 | |
| SCHEMBL29614829 | 0.72 | NPC1 (0.63) | NPC1RAB9AMAPTALDH1A1MAPK10 | |
| SCHEMBL3076524 | 0.72 | NPC1 (0.63) | NPC1RAB9AMAPTALDH1A1MAPK10 | |
| SCHEMBL9453979 | 0.70 | ALDH1A1 (0.66) | NPC1RAB9AMAPTALDH1A1MAPK10 | |
| SCHEMBL9797474 | 0.70 | BCHE (0.58) | NPC1RAB9AMAPTALDH1A1MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115654-B2 | Caspase-1 inhibitors and methods for their use | SUNESIS PHARMACEUTICALS, INC. (US) | 2006-10-03 | — | — | US | claimed |
| US-20040048895-A1 | Caspase-1 inhibitors and methods for their use | SUNESIS PHARMACEUTICALS, INC. | 2004-03-11 | — | — | US | claimed |
| WO-2003103599-A2 | CASPASE-1 INHIBITORS AND METHODS FOR THEIR USE | SUNESIS PHARMACEUTICALS, INC. (US) | 2003-12-18 | — | — | WO | claimed |
| US-7115654-B2 | Caspase-1 inhibitors and methods for their use | SUNESIS PHARMACEUTICALS, INC. (US) | 2006-10-03 | — | — | US | disclosed |
| US-20040048895-A1 | Caspase-1 inhibitors and methods for their use | SUNESIS PHARMACEUTICALS, INC. | 2004-03-11 | — | — | US | disclosed |
| WO-2003103599-A2 | CASPASE-1 INHIBITORS AND METHODS FOR THEIR USE | SUNESIS PHARMACEUTICALS, INC. (US) | 2003-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040048895-A1 | Caspase-1 inhibitors and methods for their use | CASP1, CASP2, CASP9 | NPC1 1386/4885RAB9A 2474/4885MAPT 3782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.