SCHEMBL609918

SCHEMBL609918

NC(=O)c1ccccc1C(N)=S

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.56
ALDH1A1 P00352 3/20 0.56
MAPT P10636 2/20 0.56
TSHR P16473 2/20 0.56
HSD17B10 Q99714 2/20 0.56
HPGD P15428 1/20 0.56
METAP2 P50579 1/20 0.52
BCAT2 O15382 1/20 0.50
GAA P10253 1/20 0.45
CTNNB1 P35222 1/20 0.45
SIRT1 Q96EB6 1/20 0.45
PARP1 P09874 2/20 0.44
POLB P06746 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C19 P33261 1/20 0.44
RECQL P46063 1/20 0.44
BLM P54132 1/20 0.44
PMP22 Q01453 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL39118 0.87 ALDH1A1 (0.70) KDM4EALDH1A1MAPTTSHRHSD17B10
SCHEMBL609919 0.87 ALDH1A1 (0.42) KDM4EALDH1A1MAPTTSHRHSD17B10
SCHEMBL4967588 0.87 ALDH1A1 (0.70) KDM4EALDH1A1MAPTTSHRHSD17B10
SCHEMBL27700719 0.87 ALDH1A1 (0.70) KDM4EALDH1A1MAPTTSHRHSD17B10
SCHEMBL8445150 0.84 ALDH1A1 (0.67) KDM4EALDH1A1MAPTTSHRHSD17B10
Potassium SCHEMBL317509 0.84 ALDH1A1 (0.67) KDM4EALDH1A1MAPTTSHRHSD17B10
SCHEMBL317508 0.84 ALDH1A1 (0.67) KDM4EALDH1A1MAPTTSHRHSD17B10
Hydrochloric Acid SCHEMBL8612216 0.84 ALDH1A1 (0.67) KDM4EALDH1A1MAPTTSHRHSD17B10
SCHEMBL31285706 0.84 ALDH1A1 (0.67) KDM4EALDH1A1MAPTTSHRHSD17B10
SCHEMBL1158413 0.84 ALDH1A1 (0.67) KDM4EALDH1A1MAPTTSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090133810-A1 Production method and filter comprising non woven fabric and/or filtering injector structures or sheets which are obtained using said method and which are intended for the filtration and elimination of legionella pneumophila in any installation at risk from legionella pneumophila proliferation PENALVA JOAQUIN ESPUELAS 2009-05-28 US claimed
US-20070202770-A1 Production Method and Filter Comprising Non Woven Fabric and/or Filtering Injector Structures or Sheets Which are Obtained Using Said Method and Which are Intended for the Filtration and Which are Intended for the Filtration and Elimination of Legionella Pneumofila in any Installation at Risk From Legionella Pneumofila Proliferation PENALVA JOAQUIN E 2007-08-30 US claimed
EP-1738812-A1 PRODUCTION METHOD, AND FILTER COMPRISING NON-WOVEN FABRIC AND/OR FILTERING INJECTOR STRUCTURES OR SHEETS WHICH ARE OBTAINED USING SAID METHOD AND WHICH ARE INTENDED FOR THE FILTRATION AND ELIMINATION OF LEGIONELLA PNEUMOPHILA IN ANY INSTALLATION WITH A RISK OF LEGIONELLA PNEUMOPHILA PROLIFERATION Espuelas Peñalva, Joaquin (ES) 2007-01-03 EP claimed
CN-118146128-A Thioamide compound, preparation method thereof and application thereof in fruit and vegetable preservation 湘潭大学 2024-06-07 CN disclosed
CN-116323610-A Pyrazolo [3,4-b ] pyridine-4-carboxamide nitrification inhibitors 欧洲化学安特卫普公司 2023-06-23 CN disclosed
CN-116234786-A N-heterocyclic compounds as nitrification inhibitors 欧洲化学安特卫普公司 2023-06-06 CN disclosed
US-11351164-B2 Inhibitors of indoleamine 2,3-dioxygenase and methods of their use BRISTOL-MYERS SQUIBB COMPANY (US) 2022-06-07 US disclosed
US-20210315869-A1 COMPOUNDS AND METHODS FOR CSK MODULATION AND INDICATIONS THEREFOR PLEXXIKON INC. 2021-10-14 US disclosed
WO-2021202900-A1 1,6-NAPHTHYRIDINE COMPOUNDS AND METHODS FOR CSK MODULATION AND INDICATIONS THEREFOR PLEXXIKON INC. (US) 2021-10-07 WO disclosed
US-20210283123-A1 INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE BRISTOL-MYERS SQUIBB COMPANY 2021-09-16 US disclosed
CN-108369222-B Opioid receptor modulators and uses thereof 明尼苏达大学董事会 2021-06-04 CN disclosed
EP-0783326-B1 PROCESS FOR PREPARING MACROCYCLIC CHELATING AGENTS AND FORMATION OF CHELATES AND CONJUGATES THEREOF DOW CHEMICAL CO (US) 2004-02-04 EP disclosed
EP-0783326-A1 PROCESS FOR PREPARING MACROCYCLIC CHELATING AGENTS AND FORMATION OF CHELATES AND CONJUGATES THEREOF THE DOW CHEMICAL COMPANY (US) 1997-07-16 EP disclosed
WO-1996007435-A1 PROCESS FOR PREPARING MACROCYCLIC CHELATING AGENTS AND FORMATION OF CHELATES AND CONJUGATES THEREOF THE DOW CHEMICAL COMPANY (US) 1996-03-14 WO disclosed
EP-0662842-A1 PROCESS FOR PREPARING MACROCYCLIC CHELATING AGENTS AND FORMATION OF CHELATES AND CONJUGATES THEREOF THE DOW CHEMICAL COMPANY (US) 1995-07-19 EP disclosed
WO-1993020852-A2 MACROCYCLIC CHELATING AGENTS, CHELATES AND CONJUGATES THEREOF THE DOW CHEMICAL COMPANY (US) 1993-10-28 WO disclosed
US-5143967-A Sulfur cured natural rubber dispersed with carbon black THE GOODYEAR TIRE & RUBBER COMPANY (US) 1992-09-01 US disclosed
EP-0016562-B1 POLYCHLOROPRENE RUBBER COMPOSITION FORD MOTOR COMPANY LIMITED (GB) 1983-05-25 EP disclosed
US-4269746-A A BLEND OF MERCAPTAN-MODIFIED NEOPRENE, PARTICULATE FILLERS OF LARGE-SIZE CARBON BLACK AND FINE SILICA, A SULFUR-CONTAINING CURING AGENT, AND A PLASTICIZER; AUTOMOBILE SUSPENSION BUSHINGS FORD MOTOR COMPANY (US) 1981-05-26 US disclosed
EP-0016562-A1 Polychloroprene rubber composition FORD MOTOR COMPANY LIMITED (GB) 1980-10-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11351164-B2 Inhibitors of indoleamine 2,3-dioxygenase and methods of their use IDO1, IDO2, INMT KDM4E 362/4885ALDH1A1 868/4885MAPT 2294/4885
US-20210283123-A1 INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE IDO1, IDO2, INMT KDM4E 362/4885ALDH1A1 868/4885MAPT 2294/4885
US-20210315869-A1 COMPOUNDS AND METHODS FOR CSK MODULATION AND INDICATIONS THEREFOR MC2R, SLC10A1, SLC10A2 KDM4E 3400/4885ALDH1A1 2544/4885MAPT 1831/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.