Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | EGFR | P00533 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.55 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6100618 | 0.84 | EGFR (0.56) | KMT2AEGFRTRPA1SMN1; SMN2MEN1 | |
| SCHEMBL8060535 | 0.82 | TRPA1 (0.59) | KMT2ACYP3A4CYP2C9EGFRTP53 | |
| SCHEMBL6097501 | 0.82 | KMT2A (0.72) | KMT2ACYP3A4CYP2C9TRPA1TRPM2 | |
| SCHEMBL8060537 | 0.82 | TRPA1 (0.59) | KMT2ACYP3A4CYP2C9EGFRTP53 | |
| SCHEMBL6525728 | 0.79 | TRPM2 (0.76) | KMT2ACYP3A4CYP2C9TP53TRPA1 | |
| SCHEMBL6525729 | 0.79 | TRPM2 (0.76) | KMT2ACYP3A4CYP2C9TP53TRPA1 | |
| SCHEMBL20560652 | 0.78 | CRHBP (0.58) | KMT2ACYP3A4CYP2C9EGFRTP53 | |
| SCHEMBL8048848 | 0.78 | KCNK2 (0.61) | KMT2ACYP3A4CYP2C9EGFRTP53 | |
| SCHEMBL8048849 | 0.78 | KCNK2 (0.61) | KMT2ACYP3A4CYP2C9EGFRTP53 | |
| SCHEMBL6097513 | 0.77 | MAPT (0.58) | KMT2ACYP3A4CYP2C9EGFRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053216-B2 | Modulators of Rho C activity | ICONIX PHARMACEUTICALS, INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-20030171387-A1 | Modulators of Rho C activity | ENTELOS HOLDING CORP. | 2003-09-11 | — | — | US | disclosed |
| WO-2003043961-A2 | MODULATORS OF RHO C ACTIVITY | ICONIX PHARMACEUTICALS, INC. (US) | 2003-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171387-A1 | Modulators of Rho C activity | RHOC, ROCK1, CIT | KMT2A 3564/4885CYP3A4 2850/4885CYP2C9 2362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.