Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 13/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6101031 | 0.70 | CRHR1 (0.48) | HSD11B1HSP90AA1HSP90AB1CRHR1KDM4E | |
| SCHEMBL6102731 | 0.69 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL8010081 | 0.65 | HSD11B1 (0.46) | HSD11B1HSP90AA1HSP90AB1CRHR1HPGD | |
| SCHEMBL28921919 | 0.65 | HSD11B1 (0.46) | HSD11B1HSP90AA1HSP90AB1CRHR1HPGD | |
| SCHEMBL6834931 | 0.64 | CRHR1 (0.69) | CRHR1 | |
| SCHEMBL6101843 | 0.64 | CRHR1 (0.55) | HSD11B1HSP90AA1HSP90AB1CRHR1HPGD | |
| SCHEMBL14996580 | 0.64 | HSD11B1 (0.53) | HSD11B1CRHR1 | |
| SCHEMBL29098442 | 0.64 | GUSB (0.51) | HSD11B1HSP90AA1HSP90AB1CRHR1HPGD | |
| SCHEMBL7041005 | 0.64 | HSD11B1 (0.45) | HSD11B1HSP90AA1HSP90AB1CRHR1HPGD | |
| SCHEMBL464507 | 0.63 | AHR (0.64) | HSD11B1HSP90AA1HSP90AB1CRHR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7041672-B2 | Substituted aryl 1, 4-pyrazine derivatives | PFIZER INC. (US) | 2006-05-09 | — | — | US | disclosed |
| US-6992087-B2 | Substituted aryl 1,4-pyrazine derivatives | PFIZER INC (US) | 2006-01-31 | — | — | US | disclosed |
| US-20050049257-A1 | Substituted aryl 1, 4-pyrazine derivatives | PFIZER INC | 2005-03-03 | — | — | US | disclosed |
| EP-1446387-A1 | SUBSTITUTED ARYL 1,4-PYRAZINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2004-08-18 | — | — | EP | disclosed |
| US-20030144297-A1 | Substituted aryl 1,4-pyrazine derivatives | PHARMACIA & UPJOHN COMPANY | 2003-07-31 | — | — | US | disclosed |
| WO-2003045924-A1 | SUBSTITUTED ARYL 1,4-PYRAZINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2003-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049257-A1 | Substituted aryl 1, 4-pyrazine derivatives | HTR2C, HTR4, HTR5A | HSD11B1 337/4885HSP90AA1 1394/4885HSP90AB1 1559/4885 |
| US-20030144297-A1 | Substituted aryl 1,4-pyrazine derivatives | HTR2C, HTR4, HTR5A | HSD11B1 337/4885HSP90AA1 1394/4885HSP90AB1 1559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.