Sugi Predict

Sugi Predict / Compounds / SCHEMBL610403

SCHEMBL610403

SCHEMBL610403

CC1(C)OC[C@@H](Cn2ccc(N)n2)O1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.41
▸ NPSR1 Q6W5P4 1/20 0.41
▸ TMEM97 Q5BJF2 2/20 0.41
▸ SIGMAR1 Q99720 2/20 0.41
▸ CA2 P00918 2/20 0.36
▸ HSD17B10 Q99714 3/20 0.36
▸ KDM4E B2RXH2 3/20 0.36
▸ HPGD P15428 2/20 0.36
▸ TSHR P16473 1/20 0.36
▸ GAA P10253 1/20 0.35
▸ TDP1 Q9NUW8 1/20 0.35
▸ MEN1 O00255 3/20 0.34
▸ KMT2A Q03164 3/20 0.34
▸ LMNA P02545 1/20 0.34
▸ TP53 P04637 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ PKM P14618 1/20 0.34
▸ ALOX15 P16050 1/20 0.34
▸ MAPK1 P28482 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1059613 1.00 ALDH1A1 (0.41) ALDH1A1NPSR1TMEM97SIGMAR1CA2
SCHEMBL610404 1.00 ALDH1A1 (0.41) ALDH1A1NPSR1TMEM97SIGMAR1CA2
SCHEMBL29694278 0.86 CA2 (0.35) ALDH1A1NPSR1TMEM97SIGMAR1CA2
SCHEMBL12200438 0.84 ALDH1A1 (0.45) ALDH1A1NPSR1TMEM97SIGMAR1CA2
SCHEMBL12200443 0.84 ALDH1A1 (0.45) ALDH1A1NPSR1TMEM97SIGMAR1CA2
SCHEMBL2662008 0.80 TMEM97 (0.45) ALDH1A1NPSR1TMEM97SIGMAR1CA2
SCHEMBL1080225 0.80 TMEM97 (0.45) ALDH1A1NPSR1TMEM97SIGMAR1CA2
SCHEMBL1064093 0.78 KMT2A (0.41) ALDH1A1NPSR1TMEM97SIGMAR1HSD17B10
SCHEMBL1061833 0.78 KMT2A (0.41) ALDH1A1NPSR1TMEM97SIGMAR1HSD17B10
SCHEMBL1061834 0.78 KMT2A (0.41) ALDH1A1NPSR1TMEM97SIGMAR1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112062754-B Preparation method of intermediate for synthesizing Dorzagliatin 深圳市华先医药科技有限公司 2022-06-21 — — CN claimed
CN-112062754-A Preparation method of intermediate for synthesizing Dorzagliatin 深圳市华先医药科技有限公司 2020-12-11 — — CN claimed
EP-2938609-B1 PROCESS FOR THE PREPARATION OF 1-([1,3]DIOXOLAN-4-YLMETHYL)-1H-PYRAZOL-3-YLAMINE HUA MEDICINE (KY) 2017-04-12 — — EP claimed
US-9388168-B2 Process for the preparation of 1-([1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-ylamine HUA MEDICINE (KY) 2016-07-12 — — US claimed
CN-105051031-A Process for the preparation of 1- ([1,3] dioxolan-4-ylmethyl) -1H-pyrazol-3-amine HUA MEDICINE 2015-11-11 — — CN claimed
US-20150315176-A1 Process for the Preparation of 1-([1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-ylamine HUA MEDICINE (SHANGHAI) LTD. (CN) 2015-11-05 — — US claimed
EP-2938609-A1 PROCESS FOR THE PREPARATION OF 1-([1,3]DIOXOLAN-4-YLMETHYL)-1H-PYRAZOL-3-YLAMINE Hua Medicine (CN) 2015-11-04 — — EP claimed
WO-2014102164-A1 PROCESS FOR THE PREPARATION OF 1-([1,3]DIOXOLAN-4-YLMETHYL)-1H-PYRAZOL-3-YLAMINE F. HOFFMANN-LA ROCHE AG (CH) 2014-07-03 — — WO claimed
US-8354444-B2 Substituted pyrrolidine-2-carboxamides HOFFMANN-LA ROCHE INC. (US) 2013-01-15 — — US claimed
EP-2340021-B1 SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES HOFFMANN LA ROCHE (CH) 2012-11-07 — — EP claimed
US-8258134-B2 Pyridazinone glucokinase activators HOFFMANN-LA ROCHE INC. (US) 2012-09-04 — — US claimed
EP-2274297-B1 PYRROLIDINONE GLUCOKINASE ACTIVATORS HOFFMANN LA ROCHE (CH) 2012-05-09 — — EP claimed
CN-102159207-A Substituted pyrrolidine-2-carboxamides HOFFMANN LA ROCHE 2011-08-17 — — CN claimed
US-7741327-B2 Pyrrolidinone glucokinase activators HOFFMANN-LA ROCHE INC. (US) 2010-06-22 — — US claimed
US-20100152190-A1 Substituted Pyrrolidine-2-Carboxamides F. HOFFMANN-LA ROCHE AG (CH) 2010-06-17 — — US claimed
US-20100075948-A1 Substituted Pyrrolidine-2-Carboxamides DING QINGJIE 2010-03-25 — — US claimed
US-20090264445-A1 PYRROLIDINONE GLUCOKINASE ACTIVATORS BERTHEL STEVEN JOSEPH 2009-10-22 — — US claimed
WO-2009127546-A1 PYRROLIDINONE GLUCOKINASE ACTIVATORS F. HOFFMANN-LA ROCHE AG (CH) 2009-10-22 — — WO claimed
CN-113527265-B9 Deuterated pyrrolidone derivative, pharmaceutical composition and application thereof 湖南南新制药股份有限公司 2022-07-19 — — CN disclosed
US-20090264434-A1 PYRIDAZINONE GLUCOKINASE ACTIVATORS BERTHEL STEVEN JOSEPH 2009-10-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100152190-A1 Substituted Pyrrolidine-2-Carboxamides ARG2, CCNY, PYCR1 ALDH1A1 2027/4885NPSR1 841/4885TMEM97 3271/4885
US-20090264445-A1 PYRROLIDINONE GLUCOKINASE ACTIVATORS GCKR, GCK, PDK2 ALDH1A1 1129/4885NPSR1 3628/4885TMEM97 4438/4885
US-20150315176-A1 Process for the Preparation of 1-([1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-ylamine ACTN1, ACTB, ROCK1 ALDH1A1 569/4885NPSR1 2194/4885TMEM97 2066/4885
US-20090264434-A1 PYRIDAZINONE GLUCOKINASE ACTIVATORS GCK, GCKR, PDXK ALDH1A1 1059/4885NPSR1 4397/4885TMEM97 3689/4885
US-20100075948-A1 Substituted Pyrrolidine-2-Carboxamides ARG2, CCNY, PYCR1 ALDH1A1 2027/4885NPSR1 841/4885TMEM97 3271/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.