Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | IDE | P14735 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 5/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23570044 | 0.78 | KDM4E (0.45) | ELANELMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL9980554 | 0.75 | SLC9A1 (0.45) | SLC9A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL9400073 | 0.74 | ELANE (0.52) | ELANESLC9A1MEN1KMT2AHTT | |
| SCHEMBL30302187 | 0.74 | RORC (0.54) | SLC9A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL3040501 | 0.73 | IDE (0.55) | SLC9A1LMNASMN1; SMN2HTTIDE | |
| SCHEMBL590143 | 0.73 | RORC (0.41) | SLC9A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL28171820 | 0.73 | ELANE (0.61) | ELANESCN9ALMNAMEN1KMT2A | |
| SCHEMBL21958613 | 0.73 | ELANE (0.61) | ELANESCN9ALMNAMEN1KMT2A | |
| SCHEMBL4560776 | 0.72 | SCN9A (0.76) | ELANESCN9AMEN1KMT2ARORC | |
| SCHEMBL30695134 | 0.72 | SCN9A (0.76) | ELANESCN9AMEN1KMT2ARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120130078-A1 | INDAZOLE DERIVATIVES AS ADENOSINE MONOPHOSPHATE DEAMINASE (AMPD) INHIBITORS FOR USE IN DIABETES AND RELATED DISEASES OF METABOLIC SYNDROME | OCHS RAYMOND S (US) | 2012-05-24 | — | — | US | disclosed |
| US-20120130078-A1 | INDAZOLE DERIVATIVES AS ADENOSINE MONOPHOSPHATE DEAMINASE (AMPD) INHIBITORS FOR USE IN DIABETES AND RELATED DISEASES OF METABOLIC SYNDROME | OCHS RAYMOND S (US) | 2012-05-24 | — | — | US | disclosed |
| US-20120130078-A1 | INDAZOLE DERIVATIVES AS ADENOSINE MONOPHOSPHATE DEAMINASE (AMPD) INHIBITORS FOR USE IN DIABETES AND RELATED DISEASES OF METABOLIC SYNDROME | OCHS RAYMOND S (US) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120130078-A1 | INDAZOLE DERIVATIVES AS ADENOSINE MONOPHOSPHATE DEAMINASE (AMPD) INHIBITORS FOR USE IN DIABETES AND RELATED DISEASES OF METABOLIC SYNDROME | AMPD1, AMPD3, AMPD2 | ELANE 3999/4885SCN9A 3313/4885SLC9A1 2910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.