Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.34 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.34 |
| ▸ | DNM1 | Q05193 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL23607564 | 0.95 | DNM1 (0.42) | DNM1KDM4EMAPK1HIF1AMEN1 | |
| Hydrochloric Acid SCHEMBL475592 | 0.95 | CHRM2 (0.35) | DNM1KDM4EMAPK1HIF1AMEN1 | |
| SCHEMBL1563365 | 0.93 | CHRM2 (0.36) | DNM1KDM4EMAPK1HIF1AMEN1 | |
| Hydrochloric Acid SCHEMBL475743 | 0.87 | CHRM2 (0.43) | CHRM2CYP2D6CHRM1ADRA2CCHRM3 | |
| SCHEMBL7056776 | 0.85 | CHRM2 (0.44) | CHRM2CYP2D6CHRM1ADRA2CCHRM3 | |
| SCHEMBL9820844 | 0.84 | TGFBR1 (0.33) | CHRM2CYP2D6CHRM1ADRA2CCHRM3 | |
| Bromide SCHEMBL6116969 | 0.84 | CHRM2 (0.43) | DNM1CHRM2CYP2D6CHRM1ADRA2C | |
| SCHEMBL19220240 | 0.84 | EPHX2 (0.39) | KDM4EMAPK1HIF1ATGFBR1 | |
| SCHEMBL15253793 | 0.83 | EPHX1 (0.46) | HIF1AEPHX1ALOX12PLA2G2AZDHHC20 | |
| Hydrochloric Acid SCHEMBL3112798 | 0.82 | ACHE (0.41) | DNM1KDM4EMAPK1HIF1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722824-B2 | Relative permeability modifiers based on hydrophobically modified cationic copolymers | ENI S.P.A. (IT) | 2014-05-13 | — | — | US | disclosed |
| US-20120130037-A1 | RELATIVE PERMEABILITY MODIFIERS BASED ON HYDROPHOBICALLY MODIFIED CATIONIC COPOLYMERS | ENI S.P.A. (IT) | 2012-05-24 | — | — | US | disclosed |