Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 7/20 | 0.48 |
| ▸ | PPARA | Q07869 | 7/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | ACP3 | P15309 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29649169 | 1.00 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10PPARGPPARA | |
| SCHEMBL29697583 | 1.00 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10PPARGPPARA | |
| SCHEMBL29697568 | 1.00 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10PPARGPPARA | |
| SCHEMBL2723142 | 1.00 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10PPARGPPARA | |
| SCHEMBL12940368 | 1.00 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10PPARGPPARA | |
| Mandelic Acid SCHEMBL16689936 | 0.89 | LMNA (0.47) | ALDH1A1KDM4EHSD17B10PPARGPPARA | |
| SCHEMBL9088372 | 0.85 | ALDH1A1 (0.43) | ALDH1A1KDM4EHSD17B10PPARGPPARA | |
| SCHEMBL9087816 | 0.85 | ALDH1A1 (0.43) | ALDH1A1KDM4EHSD17B10PPARGPPARA | |
| SCHEMBL9551660 | 0.85 | ALDH1A1 (0.43) | ALDH1A1KDM4EHSD17B10PPARGPPARA | |
| SCHEMBL7945062 | 0.83 | ALDH1A1 (0.41) | ALDH1A1KDM4EHSD17B10PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11865128-B2 | Aminoglycosides and uses thereof in treating genetic disorders | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2024-01-09 | — | — | US | disclosed |
| US-11613551-B2 | Aminoglycoside derivatives and uses thereof in treating genetic disorders | ELOXX PHARMACEUTICALS LTD. (IL) | 2023-03-28 | — | — | US | disclosed |
| CN-114957357-A | Aminoglycoside derivatives and their use in the treatment of genetic disorders | ELOXX制药有限公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-108350014-B | Aminoglycoside derivatives and their use in the treatment of genetic disorders | ELOXX制药有限公司 | 2022-06-10 | — | — | CN | disclosed |
| US-20210300958-A1 | AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS | ELOXX PHARMACEUTICALS LTD. (IL) | 2021-09-30 | — | — | US | disclosed |
| US-20210228608-A1 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2021-07-29 | — | — | US | disclosed |
| US-10973839-B2 | Aminoglycosides and uses thereof in treating genetic disorders | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2021-04-13 | — | — | US | disclosed |
| US-10899785-B2 | Aminoglycoside derivatives and uses thereof in treating genetic disorders | ELOXX PHARMACEUTICALS LTD. (IL) | 2021-01-26 | — | — | US | disclosed |
| EP-3296311-B1 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS | TECHNION RES & DEV FOUNDATION (IL) | 2020-09-30 | — | — | EP | disclosed |
| US-20200078386-A1 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2020-03-12 | — | — | US | disclosed |
| US-20160074425-A1 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2016-03-17 | — | — | US | disclosed |
| US-9175029-B2 | Aminoglycosides and uses thereof in treating genetic disorders | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2015-11-03 | — | — | US | disclosed |
| US-9085587-B2 | Inhibitors of hepatitis C virus | PRESIDIO PHARMACEUTICALS, INC. (US) | 2015-07-21 | — | — | US | disclosed |
| US-20140357590-A1 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2014-12-04 | — | — | US | disclosed |
| US-8895519-B2 | Aminoglycosides and uses thereof in treating genetic disorders | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2014-11-25 | — | — | US | disclosed |
| EP-2640734-A1 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS | Technion Research & Development Foundation Ltd. (IL) | 2013-09-25 | — | — | EP | disclosed |
| US-20130237489-A1 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2013-09-12 | — | — | US | disclosed |
| US-20120276051-A1 | INHIBITORS OF HEPATITIS C VIRUS | PRESIDIO PHARMACEUTICALS, INC. (US) | 2012-11-01 | — | — | US | disclosed |
| US-20120251497-A1 | INHIBITORS OF HEPATITIS C VIRUS | PRESIDIO PHARMACEUTICALS, INC. | 2012-10-04 | — | — | US | disclosed |
| WO-2012066546-A1 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. (IL) | 2012-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357590-A1 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS | AARS1, GARS1, UPF1 | ALDH1A1 2646/4885KDM4E 3261/4885HSD17B10 2530/4885 |
| US-20120276051-A1 | INHIBITORS OF HEPATITIS C VIRUS | HAVCR2, LIPC, HCCS | ALDH1A1 1654/4885KDM4E 3905/4885HSD17B10 691/4885 |
| US-20210300958-A1 | AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS | UPF1, AARS1, NUDT21 | ALDH1A1 1473/4885KDM4E 2974/4885HSD17B10 2322/4885 |
| US-20210228608-A1 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS | AARS1, GARS1, UPF1 | ALDH1A1 2646/4885KDM4E 3261/4885HSD17B10 2530/4885 |
| US-11865128-B2 | Aminoglycosides and uses thereof in treating genetic disorders | AARS1, GARS1, UPF1 | ALDH1A1 2646/4885KDM4E 3261/4885HSD17B10 2530/4885 |
| US-10973839-B2 | Aminoglycosides and uses thereof in treating genetic disorders | AARS1, GARS1, UPF1 | ALDH1A1 2646/4885KDM4E 3261/4885HSD17B10 2530/4885 |
| US-20130237489-A1 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS | AARS1, GARS1, UPF1 | ALDH1A1 2646/4885KDM4E 3261/4885HSD17B10 2530/4885 |
| US-20160074425-A1 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS | AARS1, GARS1, UPF1 | ALDH1A1 2646/4885KDM4E 3261/4885HSD17B10 2530/4885 |
| US-11613551-B2 | Aminoglycoside derivatives and uses thereof in treating genetic disorders | UPF1, AARS1, NUDT21 | ALDH1A1 1473/4885KDM4E 2974/4885HSD17B10 2322/4885 |
| US-10899785-B2 | Aminoglycoside derivatives and uses thereof in treating genetic disorders | UPF1, AARS1, NUDT21 | ALDH1A1 1473/4885KDM4E 2974/4885HSD17B10 2322/4885 |
| US-20200078386-A1 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS | AARS1, GARS1, UPF1 | ALDH1A1 2646/4885KDM4E 3261/4885HSD17B10 2530/4885 |
| US-20120251497-A1 | INHIBITORS OF HEPATITIS C VIRUS | HAVCR2, LIPC, HCCS | ALDH1A1 1654/4885KDM4E 3905/4885HSD17B10 691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.