SCHEMBL6130375

SCHEMBL6130375

COc1[c]c(C(=O)NN)c(-c2ccccc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSD P07339 1/20 0.42
HTT P42858 2/20 0.39
GAA P10253 3/20 0.38
POLB P06746 1/20 0.38
ALDH1A1 P00352 5/20 0.38
KDM4E B2RXH2 4/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
NR1H4 Q96RI1 1/20 0.38
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
LMNA P02545 2/20 0.37
HPGD P15428 1/20 0.37
PRKCZ Q05513 1/20 0.37
EGFR P00533 1/20 0.37
MAPT P10636 3/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
RAB9A P51151 1/20 0.36
BACE1 P56817 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2850552 0.84 IKBKB (0.43) HTTGAAPOLBALDH1A1KDM4E
SCHEMBL6130377 0.76 ALDH1A1 (0.42) CTSDHTTGAAPOLBALDH1A1
SCHEMBL7820403 0.70 PDE4B (0.38) HTTALDH1A1KDM4EMEN1KMT2A
SCHEMBL12505457 0.69 SQOR (0.43) HTTALDH1A1KDM4EL3MBTL1LMNA
SCHEMBL27634808 0.67 TAS1R3 (0.55) CTSDHTTGAAPOLBALDH1A1
SCHEMBL1826396 0.64 CHRNB2 (0.65) HTTGAAALDH1A1MEN1KMT2A
SCHEMBL30345390 0.64 CHRNB2 (0.65) HTTGAAALDH1A1MEN1KMT2A
SCHEMBL3568542 0.64 BCAT2 (0.47) POLBALDH1A1L3MBTL1LMNAMAPT
SCHEMBL456986 0.64 PDE4B (0.33) HTTALDH1A1MAPTBACE1
SCHEMBL8585432 0.64 HDAC7 (0.60) CTSDGAAKDM4EL3MBTL1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1406863-A4 INSECTICIDAL BIPHENYLTHIOHYDRAZIDES BASF AG (DE) 2005-06-15 EP disclosed
EP-1406863-A1 INSECTICIDAL BIPHENYLTHIOHYDRAZIDES BASF AKTIENGESELLSCHAFT (DE) 2004-04-14 EP disclosed
WO-2002098841-A1 INSECTICIDAL BIPHENYLTHIOHYDRAZIDES BASF AKTIENGESELLSCHAFT (DE) 2002-12-12 WO disclosed
US-6242647-B1 EFFECTIVE AGENTS FOR THE CONTROL OF PESTIFEROUS INSECTS, ESPECIALLY ACARINA AMERICAN CYANAMID COMPANY 2001-06-05 US disclosed
EP-0641316-B1 INSECTICIDAL PHENYLHYDRAZINE DERIVATIVES UNIROYAL CHEM CO INC (US) 1997-01-22 EP disclosed
US-5536746-A Insecticidal phenylhydrazine derivatives UNIROYAL CHEMICAL COMPANY, INC. (US) 1996-07-16 US disclosed
US-5438123-A Miticides, nematocides UNIROYAL CHEMICAL COMPANY, INC. (US) 1995-08-01 US disclosed
EP-0641316-A1 INSECTICIDAL PHENYLHYDRAZINE DERIVATIVES. UNIROYAL CHEM CO INC (US) 1995-03-08 EP disclosed
US-5367093-A Pesticides UNIROYAL CHEMICAL COMPANY, INC. (US) 1994-11-22 US disclosed
WO-1993010083-A1 INSECTICIDAL PHENYLHYDRAZINE DERIVATIVES UNIROYAL CHEMICAL COMPANY, INC. (US) 1993-05-27 WO disclosed