Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 3/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6131738 | 0.99 | CD38 (0.49) | CD38ADORA3CYP11B1CYP11B2PTPN1 | |
| SCHEMBL8428316 | 0.92 | ALOX5 (0.45) | CD38ADORA3CYP11B1CYP11B2PTPN1 | |
| Hydrochloric Acid SCHEMBL6131737 | 0.80 | CD38 (0.62) | CD38HSP90AA1ALOX5SMN1; SMN2KDM4E | |
| SCHEMBL6131735 | 0.79 | CD38 (0.64) | CD38HSP90AA1ALOX5SMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL6131736 | 0.77 | CD38 (0.54) | CD38ALOX5MCL1TDP1APP | |
| SCHEMBL30891532 | 0.75 | CD38 (0.55) | CD38ALOX5MCL1TDP1APP | |
| SCHEMBL6131749 | 0.75 | CD38 (0.55) | CD38ALOX5MCL1TDP1APP | |
| SCHEMBL7044449 | 0.70 | CD38 (0.54) | CD38HSP90AA1ALOX5SMN1; SMN2KDM4E | |
| SCHEMBL7045279 | 0.70 | CD38 (0.54) | CD38HSP90AA1ALOX5SMN1; SMN2KDM4E | |
| SCHEMBL67498 | 0.70 | ALDH1A1 (0.61) | ALOX5SMN1; SMN2KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1172090-B1 | Skin dyeing compositions comprising dihydroxyacetone and a flavylium salt non substituted in position 3 | OREAL (FR) | 2005-03-09 | — | — | EP | claimed |
| EP-1172093-B1 | Compositions for coloring the skin containing flavylium salt compounds unsubstituted in position 3 and an organomodified silicone | OREAL (FR) | 2004-12-01 | — | — | EP | claimed |
| EP-1172092-B1 | Compositions for coloring the skin containing at least one UV filter and flavylium salt compounds unsubstituted in position 3 | OREAL (FR) | 2004-09-15 | — | — | EP | claimed |