Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 5/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | SNCA | P37840 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.44 |
| ▸ | ESR1 | P03372 | 4/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | QDPR | P09417 | 1/20 | 0.38 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6131735 | 0.98 | CD38 (0.64) | CD38ALOX5GLO1DPP4SNCA | |
| SCHEMBL7045279 | 0.88 | CD38 (0.54) | CD38ALOX5GLO1DPP4SNCA | |
| SCHEMBL7044449 | 0.88 | CD38 (0.54) | CD38ALOX5GLO1DPP4SNCA | |
| Hydrochloric Acid SCHEMBL6131744 | 0.86 | CD38 (0.47) | CD38GLO1ESR2ESR1OR51E2 | |
| SCHEMBL7045086 | 0.86 | CD38 (0.79) | CD38ALOX5GLO1DPP4SNCA | |
| SCHEMBL6131748 | 0.84 | CD38 (0.49) | CD38GLO1ESR2ESR1OR51E2 | |
| Hydrochloric Acid SCHEMBL6131736 | 0.83 | CD38 (0.54) | CD38ALOX5GLO1DPP4SNCA | |
| SCHEMBL30891532 | 0.81 | CD38 (0.55) | CD38ALOX5GLO1DPP4SNCA | |
| SCHEMBL6131749 | 0.81 | CD38 (0.55) | CD38ALOX5GLO1DPP4SNCA | |
| Hydrochloric Acid SCHEMBL6131746 | 0.80 | CD38 (0.48) | CD38ALOX5APPKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050169856-A1 | Coloring composition, process of making, uses thereof | L'OREAL (FR) | 2005-08-04 | — | — | US | claimed |
| EP-1172090-B1 | Skin dyeing compositions comprising dihydroxyacetone and a flavylium salt non substituted in position 3 | OREAL (FR) | 2005-03-09 | — | — | EP | claimed |
| EP-1172093-B1 | Compositions for coloring the skin containing flavylium salt compounds unsubstituted in position 3 and an organomodified silicone | OREAL (FR) | 2004-12-01 | — | — | EP | claimed |
| EP-1172092-B1 | Compositions for coloring the skin containing at least one UV filter and flavylium salt compounds unsubstituted in position 3 | OREAL (FR) | 2004-09-15 | — | — | EP | claimed |
| US-20050169856-A1 | Coloring composition, process of making, uses thereof | L'OREAL (FR) | 2005-08-04 | — | — | US | disclosed |
| US-6558655-B2 | Substituted with at least one hydroxyl group or alkoxy radical. | Société l'Oréal S.A. (FR) | 2003-05-06 | — | — | US | disclosed |
| US-6537528-B2 | Coloration close to that of a natural tan and which may be stable over time | L'OREAL S.A. (FR) | 2003-03-25 | — | — | US | disclosed |
| US-6511656-B2 | Compositions for coloring the skin comprising at least one flavylium salt which is unsubstituted in position 3 and at least one organomodified silicone | L'OREAL S.A. (FR) | 2003-01-28 | — | — | US | disclosed |
| US-20020064507-A1 | Compositions comprising at least one UV screening agent and at least one flavylium salt which is unsubstituted in position 3, for coloring the skin, and uses thereof | L'OREAL S.A. (FR) | 2002-05-30 | — | — | US | disclosed |
| US-20020051755-A1 | Composition comprising at least one self-tanning agent chosen from monocarbonyl and polycarbonyl compounds and a flavylium salt compound which is unsubstituted in position 3, for coloring the skin, and uses thereof | L'OREAL S.A. (FR) | 2002-05-02 | — | — | US | disclosed |
| US-20020048555-A1 | Artificial tanning compositions comprising flavylium salts | SOCIETE L'OREAL S.A. (FR) | 2002-04-25 | — | — | US | disclosed |
| US-20020048556-A1 | Compositions for coloring the skin comprising at least one flavylium salt which is unsubstituted in position 3 and at least one organomodified silicone | L'OREAL S.A (FR) | 2002-04-25 | — | — | US | disclosed |
| US-6241785-B1 | HOIR DYES | L'OREAL (FR) | 2001-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020064507-A1 | Compositions comprising at least one UV screening agent and at least one flavylium salt which is unsubstituted in position 3, for coloring the skin, and uses thereof | TYR, CUTA, POLR1C | CD38 4238/4885ALOX5 2829/4885GLO1 523/4885 |
| US-20020048556-A1 | Compositions for coloring the skin comprising at least one flavylium salt which is unsubstituted in position 3 and at least one organomodified silicone | CUTA, LPO, TYR | CD38 4862/4885ALOX5 109/4885GLO1 98/4885 |
| US-20020048555-A1 | Artificial tanning compositions comprising flavylium salts | ADH7, TYR, HADHB | CD38 3003/4885ALOX5 196/4885GLO1 101/4885 |
| US-20050169856-A1 | Coloring composition, process of making, uses thereof | CUTA, TYR, POLR1C | CD38 3979/4885ALOX5 715/4885GLO1 926/4885 |
| US-20020051755-A1 | Composition comprising at least one self-tanning agent chosen from monocarbonyl and polycarbonyl compounds and a flavylium salt compound which is unsubstituted in position 3, for coloring the skin, and uses thereof | TYR, CUTA, MITF | CD38 3110/4885ALOX5 2579/4885GLO1 412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.