SCHEMBL6131818

SCHEMBL6131818

COc1cc(C(C)N2CCN(c3ccccc3C(F)(F)F)CC2)ccc1OC(C)=O

nearest known ligand 0.51

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
RBP4 P02753 2/20 0.51
UTS2R Q9UKP6 9/20 0.49
GAA P10253 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7684865 0.89 RBP4 (0.48) RBP4UTS2R
SCHEMBL6131793 0.88 GAA (0.59) UTS2RGAA
SCHEMBL6131776 0.87 UTS2R (0.52) UTS2RGAA
SCHEMBL6131867 0.86 UTS2R (0.52) RBP4UTS2RGAA
SCHEMBL6131934 0.86 UTS2R (0.52) UTS2RGAA
SCHEMBL6131808 0.85 UTS2R (0.46) RBP4UTS2RGAA
SCHEMBL6131801 0.82 KMT2A (0.52) UTS2RGAA
SCHEMBL6131819 0.78 ADRA1D (0.56) RBP4
SCHEMBL6132081 0.77 UTS2R (0.52) UTS2RGAA
SCHEMBL7686644 0.77 UTS2R (0.49) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1032559-A4 AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS AVENTIS PHARMA INC (US) 2005-05-25 EP disclosed
US-6479495-B1 SIMULTANEOUSLY TREATING DEPRESSION AND MEMORY DYSFUNCTION IN MAMMALS SUFFERING FROM MEMORY DYSFUNCTION AND DEPRESSION AVENTIS PHARMACEUTICALS INC. 2002-11-12 US disclosed
EP-1032559-A1 AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS AVENTIS PHARMACEUTICALS INC. (US) 2000-09-06 EP disclosed
WO-1999016746-A1 AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS AVENTIS PHARMACEUTICALS INC. (US) 1999-04-08 WO disclosed