Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133468 | 0.91 | ADORA2A (0.41) | HIF1AADORA2AADORA1PTGS2ADORA3 | |
| SCHEMBL6133360 | 0.86 | PTGS2 (0.42) | ADORA2AADORA1PTGS2ALDH1A1XIAP | |
| SCHEMBL6133519 | 0.85 | CYP3A4 (0.43) | ADORA2AADORA1ALDH1A1MEN1NPC1 | |
| SCHEMBL6133532 | 0.83 | PTGS2 (0.44) | ADORA2AADORA1PTGS2CYP1A2ALDH1A1 | |
| Bromide SCHEMBL6134027 | 0.83 | PTGS2 (0.40) | ADORA2AADORA1PTGS2ALDH1A1XIAP | |
| SCHEMBL6136106 | 0.83 | MAPT (0.50) | ADORA2AADORA1PTGS2ALDH1A1XIAP | |
| SCHEMBL6133383 | 0.82 | ALDH1A1 (0.43) | PTGS2ALDH1A1XIAPNPC1MAPT | |
| SCHEMBL6133757 | 0.82 | ADORA1 (0.43) | ADORA2AADORA1ADORA3ADORA2BALDH1A1 | |
| SCHEMBL6133283 | 0.82 | ADORA2A (0.44) | ADORA2AADORA1ADORA3ADORA2BALDH1A1 | |
| SCHEMBL6133821 | 0.82 | TGFBR1 (0.44) | ADORA2AADORA1PTGS2ALDH1A1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | MC2R, CYP2C9, OXTR | HIF1A 2631/4885ADORA2A 635/4885ADORA1 243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.