SCHEMBL6136318

SCHEMBL6136318

CC1CC(=O)OC(c2ccc(C3=NC(C)CC(=O)O3)cc2)=N1

nearest known ligand 0.32

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.32
NOS3 P29474 1/20 0.30
NOS2 P35228 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4046759 0.91 USP1 (0.38) SMN1; SMN2NOS3NOS2
SCHEMBL6700622 0.86 NPC1 (0.41) NOS3NOS2
SCHEMBL6698793 0.81 NOS3 (0.42) NOS3NOS2
SCHEMBL20171463 0.71
SCHEMBL6700097 0.69 MMP2 (0.32)
SCHEMBL7752306 0.68 SMN1; SMN2 (0.34) SMN1; SMN2
SCHEMBL6698121 0.68 SMN1; SMN2 (0.34) SMN1; SMN2
SCHEMBL13777987 0.68 ALDH1A1 (0.42) SMN1; SMN2NOS3
SCHEMBL4163621 0.68 ALDH1A1 (0.42) SMN1; SMN2NOS3
SCHEMBL381475 0.67 MEN1 (0.46) SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0737231-B2 THERMAL STABILIZED RESIN COMPOSITIONS KOLON INC (KR) 2005-11-02 EP disclosed
EP-0710684-B1 Preparation process of polyhydroxycarboxylic acid MITSUI CHEMICALS INC (JP) 2001-01-31 EP disclosed
EP-0737231-B1 THERMAL STABILIZED RESIN COMPOSITIONS KOLON INC (KR) 2000-03-08 EP disclosed
US-5849820-A Thermal stabilized resin compositions KOLON INDUSTRIES, INC. (KR) 1998-12-15 US disclosed
US-5770683-A Preparation process of polyhydroxycarboxylic acid MITSUI TOATSU CHEMICALS, INC. (JP) 1998-06-23 US disclosed
EP-0710684-A2 Preparation process of polyhydroxycarboxylic acid MITSUI TOATSU CHEMICALS, Inc. (JP) 1996-05-08 EP disclosed
EP-0019061-B1 PROCESS FOR PRODUCING AROMATIC POLYESTERS HAVING INCREASED DEGREES OF POLYMERIZATION AND MOULDED ARTICLES COMPOSED OF THESE POLYESTERS TEIJIN LIMITED (JP) 1984-08-08 EP disclosed
US-4291152-A CHAIN EXTENSION WITH BICYCLIC OXAZINONE OR OXAZOLONE TEIJIN LIMITED (JP) 1981-09-22 US disclosed
EP-0019061-A1 Process for producing aromatic polyesters having increased degrees of polymerization and moulded articles composed of these polyesters TEIJIN LIMITED (JP) 1980-11-26 EP disclosed