Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | NOX4 | Q9NPH5 | 7/20 | 0.32 |
| ▸ | CYBB | P04839 | 4/20 | 0.32 |
| ▸ | NOX1 | Q9Y5S8 | 3/20 | 0.32 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.31 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7607564 | 0.95 | MEN1 (0.36) | MEN1ALDH1A1GAAKMT2APTGS1 | |
| SCHEMBL4319052 | 0.72 | PTGS1 (0.47) | MEN1ALDH1A1GAAKMT2APTGS1 | |
| SCHEMBL4319057 | 0.72 | PTGS1 (0.47) | MEN1ALDH1A1GAAKMT2APTGS1 | |
| Fumaric Acid SCHEMBL4310801 | 0.72 | PTGS1 (0.37) | MEN1ALDH1A1GAAKMT2APTGS1 | |
| SCHEMBL4309973 | 0.69 | MEN1 (0.45) | MEN1ALDH1A1GAAKMT2APTGS1 | |
| SCHEMBL4309972 | 0.69 | MEN1 (0.45) | MEN1ALDH1A1GAAKMT2APTGS1 | |
| SCHEMBL4309936 | 0.67 | PTGS1 (0.40) | MEN1ALDH1A1GAAKMT2APTGS1 | |
| SCHEMBL9129357 | 0.64 | SIRT1 (0.57) | MEN1ALDH1A1GAAKMT2APTGS1 | |
| SCHEMBL9129353 | 0.64 | SIRT1 (0.57) | MEN1ALDH1A1GAAKMT2APTGS1 | |
| SCHEMBL9565692 | 0.63 | MEN1 (0.48) | MEN1ALDH1A1GAAKMT2APTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991654-B1 | NOVEL 2-(IMINOMETHYL)AMINO-PHENYL DERIVATIVES, PREPARATION, APPLICATION AS MEDICINES AND COMPOSITIONS CONTAINING SAME | SOD CONSEILS RECH APPLIC (FR) | 2005-06-15 | — | — | EP | claimed |
| US-20020042511-A1 | Neuronal Nitric oxide synthase inhibitors; use to treat ischemia | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) | 2002-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020042511-A1 | Neuronal Nitric oxide synthase inhibitors; use to treat ischemia | XDH, NOS2, NOS3 | MEN1 4366/4885KMT2A 2026/4885ALDH1A1 541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.