SCHEMBL6137702

SCHEMBL6137702

Cc1ccc(C(=O)N(Cc2ccccc2)C(=N)N)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
LIMK2 P53671 1/20 0.46
TAS2R14 Q9NYV8 1/20 0.46
GRIN2D O15399 1/20 0.45
GRIN3B O60391 1/20 0.45
GRIN1 Q05586 1/20 0.45
GRIN2A Q12879 1/20 0.45
GRIN2B Q13224 1/20 0.45
GRIN2C Q14957 1/20 0.45
GRIN3A Q8TCU5 1/20 0.45
L3MBTL1 Q9Y468 2/20 0.45
LMNA P02545 2/20 0.44
ALDH1A1 P00352 2/20 0.44
MAPT P10636 2/20 0.44
GAA P10253 1/20 0.44
HPGD P15428 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
SCN2A Q99250 1/20 0.44
TRPM8 Q7Z2W7 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6137977 0.85 AGER (0.54) MEN1KMT2ATAS2R14GRIN2DGRIN3B
SCHEMBL6137828 0.85 ACHE (0.56) MEN1KMT2ALIMK2TAS2R14L3MBTL1
SCHEMBL6139870 0.80 L3MBTL1 (0.52) MEN1KMT2AL3MBTL1LMNAHPGD
SCHEMBL3456064 0.79 KMT2A (0.70) MEN1KMT2AL3MBTL1LMNAALDH1A1
SCHEMBL3058586 0.77 GRIN2D (0.51) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL6137840 0.77 SCN5A (0.49) KMT2AL3MBTL1LMNAMAPTSCN2A
SCHEMBL3690613 0.77 GRIN2D (0.58) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL3455399 0.76 LIMK2 (0.69) MEN1KMT2ALIMK2ALDH1A1GAA
SCHEMBL27675597 0.76 HSD11B1 (0.50) MEN1KMT2AL3MBTL1LMNAALDH1A1
Hydrochloric Acid SCHEMBL27527274 0.76 GRIN2D (0.54) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1032556-A4 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE CAMBRIDGE NEUROSCIENCE INC (US) 2005-02-02 EP disclosed
EP-1032556-A1 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE CAMBRIDGE NEUROSCIENCE, INC. (US) 2000-09-06 EP disclosed
WO-1999020599-A1 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE CAMBRIDGE NEUROSCIENCE, INC. (US) 1999-04-29 WO disclosed