Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 5/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.51 |
| ▸ | CFD | P00746 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583274 | 0.87 | ALDH1A1 (0.62) | ACLYKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5279632 | 0.87 | ALDH1A1 (0.79) | ACLYKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11432530 | 0.86 | ACLY (0.57) | ACLYKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3555896 | 0.85 | ACLY (0.56) | ACLYKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10054968 | 0.84 | ACLY (0.71) | ACLYKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL222372 | 0.83 | KCNA5 (0.61) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL2276451 | 0.82 | ACLY (0.71) | ACLYKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2275253 | 0.82 | ACLY (1.00) | ACLY | |
| SCHEMBL7686172 | 0.82 | ACLY (0.71) | ACLYKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3558665 | 0.82 | SLC16A3 (0.54) | ACLYKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10017529-B2 | Metformin derivatives | BioPharma Works LLC (US) | 2018-07-10 | — | — | US | disclosed |
| US-20170247400-A1 | METFORMIN DERIVATIVES | BioPharma Works LLC | 2017-08-31 | — | — | US | disclosed |
| WO-2016044433-A2 | METFORMIN DERIVATIVES | BIOPHARMA WORKS (US) | 2016-03-24 | — | — | WO | disclosed |
| CN-102395270-B | Novel compounds, pharmaceutical compositions containing same, methods of use for same, and methods for preparing same | FASGEN INC | 2014-11-12 | — | — | CN | disclosed |
| US-20120083471-A1 | Novel Compounds, Pharmaceutical Compositions Containing Same, Methods of Use for Same, and Methods for Preparing Same | FAS SECURED CREDITORS HOLDCO, LLC | 2012-04-05 | — | — | US | disclosed |
| CN-102395270-A | Novel compounds, pharmaceutical compositions containing same, methods of use for same, and methods for preparing same | FASGEN INC | 2012-03-28 | — | — | CN | disclosed |
| EP-1579198-A1 | PHARMACEUTICAL COMPOSITIONS WITH IMPROVED DISSOLUTION | Transform Pharmaceuticals, Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| US-20050187277-A1 | Substituted azole derivatives, compositions, and methods of use | TRANSTECH PHARMA, INC. | 2005-08-25 | — | — | US | disclosed |
| WO-2004061433-A1 | PHARMACEUTICAL COMPOSITIONS WITH IMPROVED DISSOLUTION | TRANSFORM PHARMACEUTICALS, INC. (US) | 2004-07-22 | — | — | WO | disclosed |
| WO-2003082348-A1 | NANOGEL NETWORKS INCLUDING POLYION POLYMER FRAGMENTS AND BIOLOGICAL AGENT COMPOSITIONS THEREOF | SUPRATEK PHARMA INC. (CA) | 2003-10-09 | — | — | WO | disclosed |
| EP-0308820-B1 | ZINC, LEAD, AND/OR CALCIUMSALTS OF CARBOXYLIC ACIDS AND THEIR USE AS ANTICORROSIVE AGENTS | BASF Lacke + Farben AG (DE) | 1991-11-27 | — | — | EP | disclosed |
| EP-0308820-A1 | Zinc, lead, and/or calciumsalts of carboxylic acids and their use as anticorrosive agents | BASF Lacke + Farben AG (DE) | 1989-03-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10017529-B2 | Metformin derivatives | SLC5A2, SLC5A1, GLP1R | ACLY 494/4885KDM4E 1837/4885ALDH1A1 937/4885 |
| US-20170247400-A1 | METFORMIN DERIVATIVES | SLC5A2, SLC5A1, GLP1R | ACLY 494/4885KDM4E 1837/4885ALDH1A1 937/4885 |
| US-20050187277-A1 | Substituted azole derivatives, compositions, and methods of use | PTPRO, PTPN5, PTPRE | ACLY 1839/4885KDM4E 733/4885ALDH1A1 747/4885 |
| US-20120083471-A1 | Novel Compounds, Pharmaceutical Compositions Containing Same, Methods of Use for Same, and Methods for Preparing Same | LCAT, DGAT2, SOAT2 | ACLY 485/4885KDM4E 1933/4885ALDH1A1 1533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.